Risk Factors for Visual Field Deterioration in the United Kingdom Glaucoma Treatment Study.

Ophthalmology
Panayiota FountiUnited Kingdom Glaucoma Treatment Study Group

Abstract

The United Kingdom Glaucoma Treatment Study (UKGTS) investigated the visual field (VF)-preserving effect of medical treatment in open-angle glaucoma (OAG). The objective of this analysis was to identify risk factors associated with VF deterioration. Randomized, double-masked, placebo-controlled multicenter trial. Five hundred sixteen participants with previously untreated OAG were recruited prospectively in 10 United Kingdom centers. Eligibility criteria were modeled on those for the Early Manifest Glaucoma Trial. Study participants were randomized to either latanoprost 0.005% or placebo eye drops. The observation period was 2 years and involved, among other procedures, VF testing and intraocular pressure (IOP) measurement at 11 scheduled visits, with clustering of tests at baseline, 18 months, and 24 months. Guided progression analysis pattern deviation maps were used to determine VF deterioration. Cox regression was used to compute the hazard ratios (HRs) and respective 95% confidence intervals (CIs) while accounting for the correlation within sites. Model selection was guided by backward stepwise selection conducted on the model containing all variables that were significant at the 0.2 level in the univariate analysis. Follo...Continue Reading

Citations

Jul 29, 2021·American Journal of Ophthalmology·Harsha L RaoRobert N Weinreb
Oct 6, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Frances Meier-Gibbons, Marc Töteberg-Harms
Nov 4, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Karl Mercieca
Jan 31, 2022·Journal français d'ophtalmologie·S Lehrer, P H Rheinstein
Dec 14, 2021·American Journal of Ophthalmology·Harsha L RaoRobert N Weinreb

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