Risk factors in toxic megacolon

Digestive Diseases and Sciences
Renzo CaprilliGiuseppe Frieri

Abstract

A retrospective analysis of data from a series of 22 patients with toxic megacolon complicating ulcerative colitis was performed in an attempt to detect factors associated with the fatal outcome of the attack. Of the 25 clinical findings studied, significant differences between survivors (17) and nonsurvivors (5) were observed in only seven. In nonsurvivors, duration of the disease was longer and blood pH and standard bicarbonate levels higher, whereas serum potassium, calcium, phosphorus, and beta-globulins were lower. Discriminant analysis showed that three pairs of features, namely potassium-beta-globulins, potassium-bicarbonate, and potassium-blood pH provided a good discrimination between survivors and nonsurvivors. Results of this study indicate that the severity of the electrolyte and metabolic disorder appears to be an important risk factor in toxic megacolon. Intensive fluid and electrolyte replacement should therefore be considered a crucial point for successful management of toxic megacolon.

References

Jan 1, 1978·Scandinavian Journal of Gastroenterology·R CaprilliL de Magistris
Dec 1, 1978·The Journal of Clinical Investigation·T J FullerJ C Peterson
Dec 1, 1978·The Journal of Clinical Investigation·J P KnochelN W Carter
Aug 1, 1975·Gut·J E Lennard-JonesC C Spicer
Jan 1, 1975·Digestion·N ValentinK H Olesen
May 1, 1971·Lancet·C M LockwoodC G Clark
Mar 28, 1968·The New England Journal of Medicine·W E Wacker, A F Parisi
Feb 1, 1971·The Nova Scotia Medical Bulletin·M A NaqviA R Gaum
Mar 1, 1971·American Journal of Surgery·R L CollierJ Gomez

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Citations

Jan 9, 2007·Inflammatory Bowel Diseases·Stacy MeneesGrace Elta
Nov 1, 1993·Digestive Diseases and Sciences·J FallingborgS N Rasmussen
Dec 12, 1981·Lancet·P J Whorwell, P Isaacson
Feb 3, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Renzo CaprilliGiovanni Latella
Sep 1, 2008·Journal of Crohn's & Colitis·Renzo CaprilliGiuseppe Frieri
Sep 1, 1987·Digestive Diseases and Sciences·G O PerezA Rogers
Jan 29, 2008·Expert Opinion on Pharmacotherapy·Agnès BaudetJean-Marie Reimund
Mar 1, 1989·Gastroenterology Clinics of North America·S H Danovitch
May 17, 2002·The American Journal of Gastroenterology·Giovanni LatellaRenzo Caprilli
Jul 31, 1998·Postgraduate Medical Journal·Y K Viswanath, C D Griffiths
Jul 14, 2009·Neonatal Network : NN·Regina D ReynoldsPamela McKinley
Jun 24, 2017·Digestive Diseases and Sciences·Eun Soo KimUNKNOWN Crohn’s and Colitis Association in Daegu-Gyeongbuk (CCAiD)

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