Risk Factors of Bone Mass Loss at the Lumbar Spine: A Longitudinal Study in Healthy Korean Pre- and Perimenopausal Women Older than 40 Years

PloS One
Sungsu KimJong Ryeal Hahm

Abstract

Longitudinal studies on bone mass decline for healthy women are sparse. We performed a retrospective longitudinal study to evaluate the factor associated with bone mass changes at the lumbar spine in healthy Korean pre- and perimenopausal women over the age of 40. We examined the relation of blood tests including thyroid function tests at baseline and follow-up to the annual percentage changes in average BMD of L2-L4 (A%ΔLSBMD). Four hundred and forty-three subjects without diseases or medications pertaining to bone metabolism were analyzed. The mean A%ΔLSBMD in these subjects was -0.45%/year. Though a significant correlation was observed between the A%ΔLSBMD and age, serum thyroid-stimulating hormone (TSH) level, total cholesterol (TC) level, low-density lipoprotein cholesterol (LDL-C) level, and estimated glomerular filtration rate (eGFR) at baseline and follow-up, there was a weak correlation between A%ΔLSBMD and these variables. From multiple linear regression analyses, the percent body fat, age, serum TSH level, serum uric acid level, and the menopause at follow-up were showed to have a significant association with the A%ΔLSBMD. Unlike age, percent body fat, and menopause at follow-up, which had a negative association with...Continue Reading

References

Nov 1, 1992·Clinical Endocrinology·J E CompstonK T Khaw
May 1, 1993·Calcified Tissue International·J M PouillesC Ribot
Oct 1, 1996·Nature Medicine·D E HughesB F Boyce
Jun 24, 2000·JAMA : the Journal of the American Medical Association·P S WangJ Avorn
Jun 7, 2002·Endocrine Reviews·B Lawrence RiggsL Joseph Melton
Jun 26, 2002·Endocrine Journal·Toru YamaguchiKazuo Chihara
Oct 22, 2003·Cell·Etsuko AbeMone Zaidi
Sep 17, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Lian-Hua CuiJin-Su Choi
Dec 27, 2005·Current Pharmaceutical Design·G K GlantzounisD A Galaris
Sep 19, 2006·Metabolism: Clinical and Experimental·Sofia G TsouliMoses S Elisaf
Apr 24, 2007·QJM : Monthly Journal of the Association of Physicians·E M DennisonUNKNOWN Hertfordshire Cohort Study Group
Sep 12, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M SugiuraM Yano
Dec 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Joel S FinkelsteinRobert M Neer
Jul 18, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S MorinW D Leslie
Oct 18, 2008·Thyroid : Official Journal of the American Thyroid Association·Guri GrimnesRolf Jorde
May 26, 2009·Joint, Bone, Spine : Revue Du Rhumatisme·Omer Faruk SendurMukadder Serter
Oct 27, 2010·Calcified Tissue International·In-Kyong JeongChan Soo Shin
Mar 5, 2011·Current Osteoporosis Reports·Yahtyng Sheu, Jane A Cauley
May 5, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Iraj NabipourMarkus J Seibel
Oct 19, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J H KimN H Cho
Jun 16, 2012·The Journal of Clinical Endocrinology and Metabolism·Eun Young LeeSung-Kil Lim

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Citations

Jul 17, 2012·Taiwanese Journal of Obstetrics & Gynecology·Tzay-Shing YangKo-En Huang
Oct 12, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M PirroT Merriman
Feb 11, 2016·Endocrine Reviews·J H Duncan Bassett, Graham R Williams
Apr 24, 2018·Endocrine Reviews·Gherardo MazziottiAndrea Giustina
Feb 6, 2020·Experimental and Therapeutic Medicine·Sheng-Kai YeHai-Ying Chen
Aug 11, 2016·Hormone Molecular Biology and Clinical Investigation·Mone ZaidiTony Yuen
Dec 19, 2019·International Journal of Molecular Sciences·Gloria BonaccorsiCarlo Cervellati

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SPSS
R

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