Risk Factors of Clostridium Difficile Infection After Spinal Surgery: National Health Insurance Database

Scientific Reports
Sahyun SungByung Ho Lee

Abstract

The purpose of this study was to evaluate risk factors of Clostridium Difficile infection (CDI) after spinal surgery using the Health Insurance Review and Assessment Service (HIRA) data. The incidence of postoperative CDI was investigated using HIRA data from 2012 to 2016. Cases involving CDI that occurred within a 30-day postoperative period were identified. Risk factors, including age, sex, comorbidities, postoperative infection, spinal surgery procedure, type of antibiotic, and duration of antibiotic use, were evaluated. Duration of hospital stay, medical cost, and mortality were also evaluated. In total, 71,322 patients were included. Presumed cases of CDI were identified in 57 patients, with CDI rate of 0.54 per 10,000 patient days. Advanced age, staged operation, postoperative infection, and the use of multiple antibiotics were significant risk factors. First-generation cephalosporins were shown to be associated with a lower incidence of CDI. CDI was also associated with longer hospital stays and increased medical cost, and it was an independent risk factor for increased mortality. Extra attention should be paid to patients at high risk for the development of postoperative CDI, and unnecessary use of multiple antibiotics ...Continue Reading

References

Mar 31, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Carlene A MutoLee H Harrison
Sep 24, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jacques PépinBenoit Cossette
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jacques PépinLuc Lanthier
Jul 11, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Heidi T ChangDale N Gerding
Jan 4, 2008·Surgical Infections·Marc ZereyB Todd Heniford
Feb 7, 2008·Emerging Infectious Diseases·Matthew D RedelingsLaurene Mascola
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alex CarignanLouis Valiquette
Jun 7, 2008·The Journal of Arthroplasty·Mark F KurdJavad Parvizi
Jun 17, 2009·Nature Reviews. Microbiology·Maja RupnikDale N Gerding
Apr 8, 2010·JAMA : the Journal of the American Medical Association·Richard A DeyoJeffrey G Jarvik
Jul 2, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·David B Stewart, Christopher S Hollenbeak
Apr 25, 2012·The American Journal of Gastroenterology·Chun Shing KwokYoon Kong Loke
Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
Apr 9, 2013·Neurosurgery Clinics of North America·Ian McCarthyChristopher P Ames
Jul 1, 2014·Spine·Branko SkovrljSheeraz A Qureshi
May 9, 2015·American Journal of Infection Control·Jacqueline R ArgamanyKelly R Reveles
Aug 25, 2015·World Journal of Emergency Surgery : WJES·Massimo SartelliPierluigi Viale
May 18, 2016·Global Spine Journal·Javier Z GuzmanSheeraz A Qureshi

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Citations

Aug 27, 2021·American Journal of Infection Control·Dong Youn KimMi Suk Lee

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