Risk factors of gastroesophageal reflux disease: methodology and first epidemiological results of the ProGERD study

Journal of Clinical Epidemiology
M KuligS N Willich

Abstract

We describe the design and report the first results of the Progression of Gastroesophageal Reflux Disease (ProGERD) study, to our knowledge the largest prospective study of GERD patients. Patients were recruited at 1,253 centers in Germany, Austria, and Switzerland. Following an assessment of medical history, all patients were endoscoped and received esomeprazole for 2 to 8 weeks before entering the 5-year observational phase. A total of 6,215 patients (53% male, age 54+/-14) were included. Of these patients, 46% reported at least daily symptoms, 15% were unable to work at least once during the prior year, and 71% had visited a physician due to reflux symptoms. Barrett's esophagus (BE) was found in 11% of our GERD patients. In polychotomous regression analysis, the main factors related to the occurrence of the three GERD subgroups (nonerosive, erosive disease, and BE) were age, gender, duration of GERD, body mass index (BMI), smoking, and previous PPI use. Factors associated with longer disease duration were increasing age, male gender, BMI, increasing symptom severity, presence of erosive GERD or BE, positive family history, and smoking. The findings indicate that GERD is a great burden for patients, and has significant socioe...Continue Reading

References

Nov 1, 1976·The American Journal of Digestive Diseases·O T NebelD O Castell
Mar 30, 1991·BMJ : British Medical Journal·R JohnsenP G Burhol
Oct 3, 1985·The New England Journal of Medicine·A J CameronW S Payne
Nov 1, 1995·Gastroenterology·A J CameronH A Carpenter
Jul 15, 1994·International Journal of Cancer. Journal International Du Cancer·Y T GaoJ F Fraumeni
Jan 1, 1994·Scandinavian Journal of Gastroenterology. Supplement·J P Galmiche, S Bruley des Varannes
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·I Wiklund, P Butler-Wheelhouse
Jul 1, 1997·Medical Decision Making : an International Journal of the Society for Medical Decision Making·M HelfandD A Lieberman
Mar 18, 1999·The New England Journal of Medicine·J LagergrenO Nyrén
Jun 22, 1999·Annals of Internal Medicine·J LagergrenO Nyrén
Jun 23, 1999·The American Journal of Medicine·G R LockeL J Melton
Feb 24, 2001·The American Journal of Gastroenterology·M J ShawP Bytzer
Oct 11, 2001·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·E ToyotaW M Chilian
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Massimo ConioUNKNOWN Gruppo Operativo per lo Studio delle Precancerosi Esofagee (GOSPE)
Apr 23, 2002·Alimentary Pharmacology & Therapeutics·R J F LaheijJ B M J Jansen
Dec 5, 2002·Journal of Clinical Epidemiology·Carlos ManterolaLuis Bustos
Apr 5, 2003·BMJ : British Medical Journal·Anan RaghunathSusan Childs
May 14, 2003·JOP : Journal of the Pancreas·Gianpiero ManesDino Vaira

❮ Previous
Next ❯

Citations

Aug 25, 2011·Surgical Endoscopy·Koray TekinMehmet Ali Yerdel
Mar 31, 2011·Digestive Diseases and Sciences·Brian C JacobsonCharles S Fuchs
May 26, 2009·Current Gastroenterology Reports·Jeff MichalakPrateek Sharma
Jan 13, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Angela Wong, Rebecca C Fitzgerald
Sep 11, 2012·Nature Genetics·Zhan SuUNKNOWN Wellcome Trust Case Control Consortium 2
Jun 2, 2006·The New England Journal of Medicine·Brian C JacobsonCarlos A Camargo
Oct 31, 2013·Journal of the National Cancer Institute·Weronica E EkUNKNOWN BEACON study investigators
Jun 18, 2009·World Journal of Gastroenterology : WJG·Kenneth J VegaM Mazen Jamal
Oct 14, 2009·World Journal of Gastroenterology : WJG·Ichiro YoshikawaMakoto Otsuki
Feb 26, 2011·World Journal of Gastroenterology : WJG·Linda Bjork OlafsdottirBjarni Thjodleifsson
Jul 25, 2012·World Journal of Gastroenterology : WJG·Rao Milind, Stephen E Attwood
May 15, 2013·Journal of Neurogastroenterology and Motility·Hyun Jin JoHyun Chae Jung
Jan 14, 2011·Journal of Gastroenterology·Toshiaki GunjiNobuyuki Matsuhashi
Nov 1, 2011·Journal of Gastroenterology·Edoardo SavarinoVincenzo Savarino
Sep 26, 2013·Wiener klinische Wochenschrift·Johannes LenglingerSebastian F Schoppmann
Apr 15, 2006·Digestive Diseases and Sciences·Katsuhiko TsukadaShuji Yamada
Apr 17, 2007·Digestive Diseases and Sciences·Ting Kin CheungBenjamin C Y Wong
Oct 17, 2007·Digestive Diseases and Sciences·P A C GatenbyA Watson
Jul 30, 2008·Digestive Diseases and Sciences·Ronnie Fass
Dec 25, 2010·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Sushil KumarAnoop Saraya
Jan 27, 2011·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Dipti ChourasiaUday C Ghoshal
Sep 1, 2007·Current Treatment Options in Gastroenterology·Tomás Navarro-Rodriguez, Ronnie Fass
Dec 1, 2013·Clinical Journal of Gastroenterology·Jiro WatariHiroto Miwa
Jan 30, 2016·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·C LamG Liu
Mar 10, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·John DentFranco Bazzoli
Dec 8, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Julian A AbramsAlfred I Neugut
Jul 24, 2007·Gastrointestinal Endoscopy·Sachin Wani, Prateek Sharma
Jul 5, 2007·The American Journal of Geriatric Pharmacotherapy·Alison A MooreKatherine T Ward
May 8, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Justin C Y WuJoseph J Y Sung
Feb 12, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X-Q MaJ He
Feb 19, 2009·Alimentary Pharmacology & Therapeutics·P A C GatenbyA Watson
Feb 5, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Prateek SharmaSachin Wani
Jul 18, 2006·Alimentary Pharmacology & Therapeutics·P WahlqvistA Barkun
Jun 29, 2006·Alimentary Pharmacology & Therapeutics·M FullardJ D Maxwell
Oct 26, 2007·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A RuigómezJ Dent
Apr 24, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A RuigómezJ Dent
Jan 21, 2006·Alimentary Pharmacology & Therapeutics·S N WillichP Malfertheiner
Sep 21, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P J VeugelersA G Casson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.