Risk factors of local recurrence after surgery in extraabdominal desmoid-type fibromatosis: A multicenter study in Japan

Cancer Science
Yoshihiro NishidaHiroshi Koike

Abstract

This study was undertaken to clarify the risk factors, including the mutation status of CTNNB1, for the local recurrence after surgery of the rare disease desmoid-type fibromatosis. It was designed as a multiinstitutional joint research project with 7 major centers in Japan participating. The committee members of 7 major medical centers specializing in bone and soft tissue tumors formed this study group to develop clinical care guidelines. Of 196 cases with specimens and medical records collected from the 7 institutions, 88 surgically treated ones were analyzed regarding clinicopathologic prognostic factors including CTNNB1 mutation status. Excluding R2 cases (n = 3), 5-year local recurrence-free survival (LRFS) was 52.9%. No case had received pre- or postoperative radiotherapy. Univariate analysis revealed that extremity location (P < .001) and larger size (8 cm or more, P = .036) were significant adverse risk factors for LRFS. Multivariate analysis indicated that extremity location (P < .001) was a significantly adverse factor in addition to recurrent tumor (P = .041), S45F mutation (P = .028), and R1 surgical margin (P = .039). Preoperative drug treatment, including nonsteroidal antiinflammatory drugs, did not reduce the inc...Continue Reading

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Citations

Oct 2, 2020·Current Opinion in Obstetrics & Gynecology·Ilaha IsaliSherif El-Nashar
Mar 3, 2021·Current Treatment Options in Oncology·Wen Shen LooiMichael S Rutenberg
Oct 1, 2021·Scientific Reports·Yoshihiro NishidaShiro Imagama

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Methods Mentioned

BETA
surgical resection
biopsy

Software Mentioned

SPSS Statistics

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