Risk factors of multidrug-resistant Acinetobacter baumannii recurrence after successful eradication in ventilated patients

Biomedical Journal
Chiung-Yu LinAn-Shen Lin

Abstract

Clinically, multidrug-resistant Acinetobacter baumannii (MDR-AB) recurrence is found in some patients although identified as successfully eradicated. We aim to discover the characteristics of patients with MDR-AB recurrence in the respiratory tract. We retrospectively collected 106 chronic respiratory failure patients with MDR-AB harvest in pulmonary secretion culture. MDR-AB was successfully eradicated in 69 patients. Diabetes mellitus (p = 0.030, odds ratio [OR]: 2.7, 95% confidence interval [CI]: 1.1-6.4) and acute respiratory distress syndrome (p = 0.001, OR = 4.8, 95% CI: 1.8-12.7) reduce the MDR-AB eradication rate. Besides, a classification of colonization or infection was made beyond the 69 MDR-AB eradicated patients. In the colonization group, diabetes mellitus (p = 0.009; OR = 5.1, 95% CI: 1.5-17.6) is the only independent factor to increase the recurrence rate. Glycated hemoglobin level is also analyzed for each group to investigate diabetes control effect, but no significant difference found. Diabetes mellitus is a risk factor of MDR-AB recurrence among MDR-AB-colonized patients; the impact of localized pneumonia patch in MDR-AB-infected patients requires further study to be clarified.

References

Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Aug 1, 1982·Antimicrobial Agents and Chemotherapy·M DevaudB Bächi
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Aug 1, 1994·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·H SeifertG Pulverer
Jun 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J M CisnerosA R Cobacho
Nov 27, 1999·FEMS Immunology and Medical Microbiology·S E Geerlings, A I Hoepelman
May 3, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Maria Virginia Villegas, Alan I Hartstein
Dec 3, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Zeina A KanafaniSouha S Kanj
Sep 8, 2004·The Journal of Hospital Infection·D Pittet
Aug 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert GaynesNational Nosocomial Infections Surveillance System
Jul 25, 2007·Antimicrobial Agents and Chemotherapy·Federico PerezRobert A Bonomo
Nov 17, 2007·Nature Reviews. Microbiology·Lenie DijkshoornHarald Seifert
Jun 18, 2009·Critical Care Medicine·Shyoko Honiden, Michelle N Gong
Jan 22, 2010·International Journal of Antimicrobial Agents·Jeong-Ah KwonHa Young Oh
Sep 13, 2011·Annals of Intensive Care·Herbert SpapenPatrick M Honoré
Oct 18, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S-C KuoC-P Fung
Dec 3, 2014·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hsiu-Mei WeiKao-Pin Hwang

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