Risk factors of postictal generalized EEG suppression in generalized convulsive seizures

Neurology
Veriano AlexandreREPO2MSE study group

Abstract

To identify the clinical determinants of occurrence of postictal generalized EEG suppression (PGES) after generalized convulsive seizures (GCS). We reviewed the video-EEG recordings of 417 patients included in the REPO2MSE study, a multicenter prospective cohort study of patients with drug-resistant focal epilepsy. According to ictal semiology, we classified GCS into 3 types: tonic-clonic GCS with bilateral and symmetric tonic arm extension (type 1), clonic GCS without tonic arm extension or flexion (type 2), and GCS with unilateral or asymmetric tonic arm extension or flexion (type 3). Association between PGES and person-specific or seizure-specific variables was analyzed after correction for individual effects and the varying number of seizures. A total of 99 GCS in 69 patients were included. Occurrence of PGES was independently associated with GCS type (p < 0.001) and lack of early administration of oxygen (p < 0.001). Odds ratio (OR) for GCS type 1 in comparison with GCS type 2 was 66.0 (95% confidence interval [CI 5.4-801.6]). In GCS type 1, risk of PGES was significantly increased when the seizure occurred during sleep (OR 5.0, 95% CI 1.2-20.9) and when oxygen was not administered early (OR 13.4, 95% CI 3.2-55.9). The ris...Continue Reading

References

Oct 1, 2010·Annals of Neurology·Samden D LhatooJonathan M Bird
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Nov 5, 2011·Epilepsia·Mira SemmelrochLina Nashef
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Citations

Sep 4, 2015·Neurology·Orrin Devinsky, Lina Nashef
Aug 6, 2016·Epilepsy & Behavior : E&B·Dirk-Matthias AltenmüllerRainer Surges
Aug 30, 2016·Lancet Neurology·Orrin DevinskyGeorge Richerson
May 24, 2018·Epilepsia·Orrin DevinskyDaniel Friedman
Jun 7, 2018·Epilepsia·Philippe RyvlinSandor Beniczky
Dec 21, 2018·Neurology·Sylvain RheimsUNKNOWN REPO2MSE study group
Jul 25, 2019·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Damon P CardenasJose E Cavazos
Apr 10, 2020·Expert Review of Neurotherapeutics·Max Christian PenselRainer Surges
Jun 11, 2020·Epilepsia·Sándor BeniczkyPhilippe Ryvlin
May 28, 2020·Epilepsia·Elisa BrunoUNKNOWN RADAR-CNS Consortium
Nov 20, 2016·Epilepsia·Daniel M GoldenholzWilliam H Theodore
Jan 9, 2019·Frontiers in Neurology·Benton S PurnellGordon F Buchanan
Dec 11, 2019·Epilepsia Open·Robert D NassRainer Surges
Aug 26, 2016·G3 : Genes - Genomes - Genetics·Arunesh Saras, Mark A Tanouye
Jan 17, 2019·Brain : a Journal of Neurology·Inge C M LoonenElse A Tolner
Jun 2, 2020·Current Medical Research and Opinion·Boulenouar MesraouaAli A Asadi-Pooya
Dec 4, 2020·Neurology·Alica M Goldman
Jan 26, 2021·Epilepsy & Behavior : E&B·Aileen McGonigalEric Guedj
Dec 29, 2020·BMC Medical Informatics and Decision Making·Cong ZhuGuo-Qiang Zhang
Feb 10, 2021·Epilepsy & Behavior : E&B·Madeleine Grigg-Damberger, Nancy Foldvary-Schaefer
Mar 2, 2021·Frontiers in Neurology·Manuela Ochoa-UrreaSamden D Lhatoo
May 25, 2021·Epilepsy Currents·Orrin Devinsky, Sanjay M Sisodiya
May 29, 2021·Frontiers in Neurology·Xiuhe ZhaoNuria Lacuey
Jul 27, 2021·Acta Neurologica Scandinavica·Alexander Nicholas SmithRohit Shankar
Jun 21, 2020·Seizure : the Journal of the British Epilepsy Association·Maria Teresa FariaElisabete Martins
Aug 25, 2018·Seizure : the Journal of the British Epilepsy Association·Marjan AsadollahiKurosh Gharagozli

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