Risk factors of recurrence after postoperative electron beam radiation therapy for keloid: Comparison of long-term local control rate.

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology
Hitoshi MaemotoSadayuki Murayama

Abstract

To investigate the new risk factors for keloid recurrence after postoperative electron beam radiotherapy (RT) and evaluate the effectiveness of tranilast in combination with electron beam RT by comparing the local control rate. Identifying patients at high risk of recurrence after postoperative RT for keloids remains a challenge. Besides, no study examined the effectiveness of tranilast in combination with RT after surgery for the prevention of keloids recurrence. This study included 75 lesions in 59 consecutive patients who had undergone postoperative RT at our institute. The follow-up period and prescription of tranilast were examined beside several potential risk factors, such as multiple lesions, size, and shape. The median follow-up was 72 months (range, 6-147 months). Twenty-one lesions in 17 patients recurred in a median of 12 months after treatment (range, 1-60 months). Local control rates of all 75 lesions were estimated as 93%, 78%, 70%, and 68% at 1, 2, 5, and 10 years. Multiple lesions constituted a significant risk of recurrence (P = 0.03). A larger long axis was significantly related to the recurrence (P < 0.01). Irregular shape was associated with a significantly worse local control rate (P = 0.02). There was no ...Continue Reading

References

Jul 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J J Kovalic, C A Perez
Oct 1, 1988·International Journal of Radiation Oncology, Biology, Physics·T L BorokC Rollins
Oct 1, 1994·Journal of Biochemistry·H YamadaS R Pinnell
Aug 1, 1994·Journal of the American Academy of Dermatology·D I KlumparM Anscher
Jun 1, 1996·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·A P SclafaniT Romo
Apr 24, 2001·International Journal of Radiation Oncology, Biology, Physics·B GuixA Martínez
Apr 25, 2003·Plastic and Reconstructive Surgery·Raj RagoowansiJohn P Glees
Jul 15, 2004·The Australasian Journal of Dermatology·Quan DinhShawn Richards
Dec 23, 2008·International Journal of Radiation Oncology, Biology, Physics·Gustavo A VianiLigia I De Fendi
Apr 14, 2009·International Journal of Radiation Oncology, Biology, Physics·Henk B KalIna M Jürgenliemk-Schulz
Nov 26, 2009·Plastic and Reconstructive Surgery·Rei OgawaTsuguhiro Miyashita
Apr 15, 2011·Journal of Radiation Research·Shigehiko KuribayashiShinichiro Kumita
Oct 30, 2013·Plastic and Reconstructive Surgery·Rei OgawaHiko Hyakusoku
Apr 29, 2014·Burns : Journal of the International Society for Burn Injuries·Anna I ArnoMarc G Jeschke
Aug 28, 2014·Plastic and Reconstructive Surgery·Michiel C E van LeeuwenFrank B Niessen
Mar 3, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Juri ArimaRei Ogawa
Mar 14, 2017·International Journal of Molecular Sciences·Rei Ogawa

❮ Previous
Next ❯

Citations

Nov 26, 2020·Journal of Clinical Medicine·Yu-Fang LinChen-Hsi Hsieh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
H SuzawaS Hamano
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology
T Waseda
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Sara Darakhshan, Ali Bidmeshki Pour
© 2022 Meta ULC. All rights reserved