Risk factors of recurrence in T1 colorectal cancers treated by endoscopic resection alone or surgical resection with lymph node dissection

International Journal of Colorectal Disease
Yuta KouyamaShigeharu Hamatani

Abstract

The recurrence of T1 colorectal cancers is relatively rare, and the prognostic factors still remain obscure. This study aimed to clarify the risk factors for recurrence in patients with T1 colorectal cancers treated by endoscopic resection (ER) alone or surgical resection (SR) with lymph node dissection, respectively. We reviewed 930 patients with resected T1 colorectal cancers (mean follow-up, 52.3 months). Patients were divided into two groups: those who underwent ER alone (298 cases), and those who underwent initial or additional SR with lymph node dissection (632 cases). Group differences in recurrence-free survival were evaluated using the Kaplan-Meier method and log-rank test. Associations between recurrence and clinicopathological features were evaluated in Cox regression analyses; hazard ratios (HRs) were calculated for the total population and each group. Recurrence occurred in four cases (1.34%) in the ER group and six cases (0.95%) in the SR group (p = 0.32). Endoscopic resection, rectal location, and poor or mucinous (Por/Muc) differentiation were prognostic factors for recurrence in the total population. Por/Muc differentiation was prognostic factor in both groups. Female sex, depressed-type morphology, and lymphat...Continue Reading

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Citations

Sep 10, 2020·Endoscopy International Open·Kim GijsbersUNKNOWN (on behalf of the Dutch T1 CRC Working Group)
Oct 13, 2020·United European Gastroenterology Journal
Oct 29, 2020·International Journal of Colorectal Disease·Yuan TianYongchen Ma
Jan 30, 2021·Clinical and Translational Gastroenterology·Shin-Ei KudoKoshi Mimori
Dec 4, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hao DangJurjen J Boonstra
Dec 24, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Katsuro IchimasaMasashi Misawa

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