Risk factors of sepsis following pancreaticoduodenectomy based on inflammation markers and clinical characteristics

ANZ Journal of Surgery
Haoyun ZhangShichun Lu

Abstract

Sepsis is a common complication following pancreaticoduodenectomy (PD). The aim of this study was to evaluate the risk factors of sepsis based on serum inflammatory markers and clinical characteristics in patients who underwent PD. A total of 138 patients were enrolled in this study and all patients underwent curative PD. Logistic regression analysis was performed to identify risk factors for post-operative sepsis. The patients' basic clinical features and inflammatory biomarkers including cytokines (IL-1, IL-2, IL-6, IL-8, IL-10 and tumour necrosis factor-α), procalcitonin, C-reactive protein and peripheral neutrophil to lymphocyte ratio were analysed. Of 138 patients, 31 developed sepsis during hospitalization. Univariate logistic regression analysis showed that body mass index, blood transfusion, operative time, American Society of Anesthesiologists score and diabetes were significant predictors of sepsis among all clinical characteristic variables. IL-2, IL-6, IL-10, procalcitonin and C-reactive protein were significant predictors among all inflammation biomarkers. By including different variables, three different regression models were obtained. The full model including all predictors mentioned above showed a C-index of 0....Continue Reading

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