Risk factors of subclinical hypothyroidism and the potential contribution to miscarriage: A review

Reproductive Medicine and Biology
Shuhei So, Fumiko Tawara

Abstract

There is no clear cutoff value for thyroid-stimulating hormone (TSH) level that defines subclinical hypothyroidism (SCH). Moreover, TSH levels can be affected by numerous factors. Although mild SCH has been implicated in miscarriage, the relationship between TSH levels and miscarriage remains unelucidated. We reviewed nine known risk factors affecting TSH levels and 28 studies investigating the potential association between mild SCH and miscarriage, examining whether these factors were considered. Among 28 studies that examined whether mild SCH (TSH > 2.5 mIU/L) contributed to miscarriage, thyroid antibodies were measured in only 15. TSH measurement methods were described in 18 studies. Although the iodinated contrast medium used in hysterosalpingography (HSG) is stored in the body for a long time and is a risk factor for mild SCH, only one study described its potential impact on TSH levels. Nine studies, which concluded that mild SCH contributed to miscarriage, had thyroid status evaluated only after the onset of pregnancy, but not before. TSH levels can be significantly affected by patient demographics and health history, country of origin, and fertility treatment. It is important to consider these factors while evaluating mi...Continue Reading

References

Jul 1, 1975·The Journal of Clinical Endocrinology and Metabolism·J WeekeK Lundaek
Dec 1, 1975·The Journal of Clinical Endocrinology and Metabolism·C LuckeA von zur Mühlen
Feb 1, 1990·The Journal of Clinical Endocrinology and Metabolism·C A SpencerJ T Nicoloff
Aug 1, 1990·The Journal of Clinical Endocrinology and Metabolism·D GlinoerB Lejeune
Sep 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S MariottiA Pinchera
Jul 1, 1972·Clinical Science·Y C PatelH G Burger
Jul 1, 1995·European Journal of Endocrinology·V KamatR T Rubin
Mar 1, 1993·Obstetrics and Gynecology·A S LeungJ H Mestman
Oct 26, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·S ChakrabortiS K Batabyal
Jun 6, 2000·The American Journal of Clinical Nutrition·M RosenbaumR L Leibel
Jan 3, 2001·The Journal of Clinical Investigation·M HarrisA N Hollenberg
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Yaron TomerTerry F Davies
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Joseph G HollowellLewis E Braverman
Feb 13, 2002·Thyroid : Official Journal of the American Thyroid Association·M AbalovichO Levalle
Feb 21, 2003·Thyroid : Official Journal of the American Thyroid Association·Yaron TomerDavid A Greenberg
Jul 17, 2003·Clinical Endocrinology·Ramazan SariUmit Karayalcin
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·J E CollinsS C L Gough
Feb 7, 2004·Endocrinology·Feifan GuoAnthony N Hollenberg
Mar 20, 2004·Lancet·J H Lazarus, F Delange
May 26, 2004·Brain, Behavior, and Immunity·Stoyan DimitrovJan Born
Jun 29, 2004·European Journal of Clinical Nutrition·M Zimmermann, F Delange
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Kris PoppeBrigitte Velkeniers
Aug 17, 2004·Thyroid : Official Journal of the American Thyroid Association·Sandra M McLachlan, Basil Rapoport
Mar 24, 2005·Thyroid : Official Journal of the American Thyroid Association·Henry VölzkeWieland Meng
May 5, 2005·The Journal of Clinical Endocrinology and Metabolism·Nils KnudsenTorben Jørgensen
Aug 18, 2005·European Journal of Human Genetics : EJHG·Bryan M DechairoStephen C Gough
Apr 20, 2006·The Journal of Clinical Endocrinology and Metabolism·Roberto NegroHaslinda Hassan
May 30, 2006·American Journal of Obstetrics and Gynecology·Valerie L BakerG David Adamson
Apr 26, 2007·Annals of Clinical Biochemistry·Geoff Beckett, Finlay MacKenzie
Feb 14, 2008·The Journal of Clinical Endocrinology and Metabolism·Yushu LiWeiping Teng
Mar 28, 2008·The Journal of Clinical Endocrinology and Metabolism·W RussellR J Ross
May 29, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Kris PoppeDaniel Glinoer
Oct 30, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Keiko MekaruYoichi Aoki
Jan 20, 2009·Journal of Biological Rhythms·Namni GoelDavid F Dinges
Jun 10, 2010·Nature Reviews. Endocrinology·Daniel Glinoer, Carole A Spencer
Jun 11, 2010·The Journal of Clinical Endocrinology and Metabolism·Roberto NegroAlex Stagnaro-Green
Aug 6, 2010·The Journal of Clinical Endocrinology and Metabolism·Bernadette Biondi
Feb 18, 2011·Thyroid : Official Journal of the American Thyroid Association·Kathleen L CaldwellRichard Y Wang

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