Risk factors of suicidal ideation in Huntington's disease: literature review and data from Enroll-HD

Journal of Neurology
Philipp HonrathEnroll-HD investigators

Abstract

Suicide is a leading cause of death in Huntington's disease (HD), following pneumonia. Up to one-fifth of individuals with HD report suicidal ideation. Identifying the risk factors of suicidal ideation in this clinical population is thus pivotal. Here, we review the literature on prevalence rates and risk factors of suicidal ideation in premanifest and manifest patients and re-evaluate them using the largest currently existing clinical dataset from the ongoing observational study "Enroll-HD" (N = 5709). Large scale studies yielded important insights regarding suicidal ideation in HD. However, estimated prevalence rates vary among studies and risk factors are still poorly understood. According to the Enroll-HD data, pre- and manifest disease stages are associated with current (5.8-10%) and a history of suicidal ideation (18.6-30.9%). Throughout the course of HD, a history of suicidal ideation and the presence of depressive symptoms were strongly associated with current suicidal ideation. However, while for premanifest individuals, socio-demographics and activities of daily living appear to be important, in manifest patients, suicidal ideation is more closely linked to anxiety, irritability, psychosis, and apathy. These results h...Continue Reading

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Citations

Mar 10, 2019·Neurology·Andrew McGarryUNKNOWN Huntington Study Group 2CARE Investigators and Coordinators
Aug 6, 2019·Journal of Huntington's Disease·Elise KaysonUNKNOWN Huntington Study Group PHAROS Investigators
Aug 20, 2019·Journal of Huntington's Disease·Noelle E CarlozziRebecca E Ready
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Mar 16, 2019·Journal of Affective Disorders·Zachary R KachianJordan Grafman
Jul 21, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·K A Gasenko, A V Arslanova
Aug 21, 2021·Practical Neurology·Thomas B StokerRoger A Barker

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