Risk Factors of the Invasive Breast Cancer Locoregional Recurrence

BioMed Research International
R V LiubotaV V Zaychuk

Abstract

The aim of the research was to estimate the frequency of the locoregional breast cancer recurrence appearance, the recurrence-free period continuance, and the 3- and 5-year survival depending on the scope of the surgical intervention, menstrual profile, and histological and molecular-biologic characteristics of the primary tumor. Among 218 patients with a breast cancer, 99 patients had breast-conserving surgery (BCS) and 119 underwent radical mastectomy (RME); all patients had regional lymphatic nodes dissection. The size and the primary tumor differentiation degree, metastasis presence in the regional lymph nodes, ER expression, PR, and Her/2neu were assessed as the prognostics factors. It was defined that the locoregional recurrence appearance frequency in patients with BCS turned out to be 13%, and in patients after RME it turned out to be 9%; the recurrence-free period continuance was 53 ± 8 months and 56 ± 10 months, respectively. The locoregional cancer recurrence frequency is higher in women with the menstrual function being preserved at the moment of the primary tumor detection than in postmenopausal patients and also in patients having the hyperexpression of the Her/2neu. The ipsilateral cancer recurrence decreases the...Continue Reading

References

Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A C VoogdUNKNOWN Danish Breast Cancer Cooperative Group. Breast Cancer Cooperative Group of the European Organization for Research and Treatm
Dec 26, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lorenzo LiviGiampaolo P Biti
Oct 17, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E BotteriU Veronesi

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Methods Mentioned

BETA
dissection
X-ray
biopsy

Software Mentioned

GLOBOCAN

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