Risk factors predictive of chronic postsurgical neuropathic pain: the value of the iliac crest bone harvest model

Pain
V MartinezDominique Fletcher

Abstract

Nerve lesions and secondary hyperalgesia may both be present after surgery, and their relative contributions to chronic postsurgical neuropathic pain (CPSNP) remain unclear. This prospective study explored the roles of these factors in the development of CPSNP after iliac crest bone harvest. CPSNP was defined as pain in the area of hypoesthesia, with a positive Douleur neuropathique 4 questionnaire (DN4) score 3 months after iliac crest bone harvest. The location, intensity, and neuropathic characteristics of pain were evaluated in 82 patients who were followed for 6 months. Neuropathic characteristics were assessed by clinical examination and DN4 questionnaire. The area of secondary hyperalgesia was evaluated 48 h and 1 month after surgery. The area of mechanical hypoesthesia, detection, and mechanical pain threshold were evaluated at 48 h and at 1 and 3 months. Nineteen patients (23%) had CPSNP at 3 months. The patients who developed CPSNP had a larger area of secondary hyperalgesia at 48 h (88 cm(2) vs 33 cm(2); P=.001), higher pain intensity (numerical rating scale 6.7 vs 4.7; P=.02), and higher neuropathic characteristics score on the DN4 questionnaire (4.3 vs 2.3; P=.001). However, neither the area nor the severity of hyp...Continue Reading

References

Aug 1, 1989·The Journal of Bone and Joint Surgery. British Volume·B N Summers, S M Eisenstein
Sep 1, 1994·The British Journal of Surgery·G StiffB I Rees
Jul 1, 1997·The Annals of Thoracic Surgery·F BenedettiG Maggi
May 20, 2000·Acta Neurologica Scandinavica. Supplementum·N Attal, D Bouhassira
Jun 5, 2002·Pain·Oliver H G Wilder-SmithLars Arendt-Nielsen
Jul 30, 2004·Anesthesia and Analgesia·Trine MikkelsenHenrik Kehlet
Aug 26, 2004·Pain·Elon Eisenberg
Nov 9, 2004·British Journal of Anaesthesia·E Aasvang, H Kehlet
Feb 9, 2005·Journal of Spinal Disorders & Techniques·Rick C SassoUNKNOWN Spine Interbody Research Group
Jan 19, 2006·Regional Anesthesia and Pain Medicine·James C Eisenach
Mar 2, 2006·Anesthesiology·Oliver H G Wilder-Smith, Lars Arendt-Nielsen
May 20, 2006·Hernia : the Journal of Hernias and Abdominal Wall Surgery·E K AasvangH Kehlet
Nov 3, 2007·Pain·Eske Kvanner AasvangHenrik Kehlet
Apr 25, 2008·British Journal of Anaesthesia·W A Macrae
Dec 20, 2008·Nature Reviews. Neuroscience·Erin D Milligan, Linda R Watkins
Sep 22, 2009·Interactive Cardiovascular and Thoracic Surgery·Robert D SearleMichael I Bennett
Mar 18, 2010·Anesthesiology·Eske K AasvangHenrik Kehlet
May 28, 2010·Journal of Pain & Palliative Care Pharmacotherapy·Oliver Hamilton Wilder-SmithLars Arendt-Nielsen
Apr 5, 2011·European Journal of Pain : EJP·Nadine AttalRolf-Detlef Treede
Jul 7, 2011·The Spine Journal : Official Journal of the North American Spine Society·Serena S Hu
Mar 28, 2013·Perspectives in Clinical Research·Pratibha Pereira

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Citations

Nov 22, 2013·Clinical Orthopaedics and Related Research·Patricia M Lavand'hommeEmmanuel Thienpont
May 14, 2014·Annales Françaises D'anesthèsie Et De Rèanimation·M ArtusH Beloeil
Jul 6, 2014·The Journal of Pain : Official Journal of the American Pain Society·RobertD Searle
Sep 3, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Érica C MarchioriFelice S O'Ryan
Jul 17, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ian R CarrollSean C Mackey
Jun 12, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·V MartinezD Fletcher
Jun 12, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·M Chauvin
Oct 21, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Philippe RichebéVéronique Brulotte
May 26, 2015·Anaesthesia Critical Care & Pain Medicine·Régis FuzierJean-Philippe Maguès
Feb 17, 2015·La Presse médicale·Patricia Lavand'homme
Jan 31, 2017·Pain·Patricia Lavand'homme
Apr 4, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Avi A Weinbroum
Oct 4, 2018·Pain Management·Alexander Schnabel
Jan 31, 2018·Drugs·Arnaud Steyaert, Patricia Lavand'homme
Sep 6, 2017·European Journal of Anaesthesiology·Arnaud Steyaert, Patricia Lavand'homme
Apr 25, 2017·European Journal of Anaesthesiology·Helene BeloeilUNKNOWN SFAR research network
Jan 1, 2016·Scandinavian Journal of Pain·Linda Block
Dec 27, 2018·Pain·Stephan A SchugUNKNOWN IASP Taskforce for the Classification of Chronic Pain
May 29, 2018·Spine Surgery and Related Research·Koki AbeSeiji Ohtori
Jun 6, 2020·European Journal of Pain : EJP·Timothée CayrolEmanuel N van den Broeke
Nov 11, 2017·British Journal of Pain·Patricia Lavand'homme
Jan 12, 2019·Brain Structure & Function·Morten Sejer HansenMohammad Sohail Asghar
Jun 26, 2020·Physiological Reviews·Nanna Brix FinnerupTroels Staehelin Jensen
Jan 21, 2021·Der Schmerz·Esther Pogatzki-Zahn
Dec 18, 2019·Orthopaedics & Traumatology, Surgery & Research : OTSR·Anissa BelbachirDavid Biau
Oct 23, 2020·Pain·Blair H SmithAbirami Veluchamy
Jan 21, 2020·British Journal of Anaesthesia·Ryu KomatsuPamela D Flood
Nov 26, 2019·Innovative Surgical Sciences·Stephan M Freys, Esther Pogatzki-Zahn
Oct 30, 2016·Journal of Visceral Surgery·H Beloeil, L Sulpice

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