Risk factors predictive of lymph node metastasis in depressed early gastric cancer

American Journal of Surgery
Nobutsugu AbeYutaka Atomi

Abstract

This study was conducted to identify risk factors predictive of regional lymph node metastasis in depressed early gastric cancer and further to establish an objective criterion useful to indicate additional surgical treatment in cases in which submucosal tumor extension becomes evident by endoscopic mucosal resection (EMR). Data from 276 patients surgically treated for depressed early gastric cancer were collected, and the relationship between the patient and tumor characteristics, and the lymph node metastasis was retrospectively evaluated by multivariate analysis. In the multivariate logistic regression model, female sex, a larger tumor size (20 mm or more), submucosal invasion, and presence of lymphatic vessel involvement were found to be independent risk factors for lymph node metastasis. Among 145 patients with submucosally invasive carcinoma, no lymph node metastasis was observed in patients who showed none of the other three risk factors, whereas 14.3% and 23.3% of patients with one and two of these factors had lymph node metastasis, respectively. The lymph node metastasis rate was calculated to be 86.7% in patients who had all three factors. Submucosal invasion, female sex, tumor size of 20 mm or more, and lymphatic ves...Continue Reading

References

Mar 1, 1992·The British Journal of Surgery·T SanoT Muto
Mar 1, 1992·The British Journal of Surgery·Y MaeharaK Sugimachi
Jul 1, 1989·American Journal of Surgery·H ItohF Nakayama
Nov 1, 1994·Endoscopy·S ShimizuK Kawai
Dec 1, 1995·The Journal of Pathology·R RanaldiI Bearzi
Apr 1, 1996·Seminars in Roentgenology·N T Wolfman, D J Ott
Nov 15, 1997·The British Journal of Surgery·T Rösch
Aug 17, 1999·Seminars in Surgical Oncology·H MakuuchiH Tanaka
Jun 27, 2001·American Journal of Surgery·T MasakiT Muto

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Citations

May 11, 2004·Langenbeck's Archives of Surgery·Norihiro Yuasa, Yuji Nimura
Mar 10, 2006·Langenbeck's Archives of Surgery·Gianni MuraGiorgio M Verdecchia
Apr 17, 2013·Surgical Endoscopy·Da Hyun JungSung Hoon Noh
Nov 28, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Mototsugu FujiiYuro Shibayama
Jul 28, 2004·Gastrointestinal Endoscopy·Nobutsugu AbeYutaka Atomi
Jul 10, 2003·The Lancet Oncology·Takashi YokotaHidemi Yamauchi
Sep 28, 2007·Annals of Surgical Oncology·Keun Won RyuJae-Moon Bae
Nov 5, 2010·World Journal of Gastroenterology : WJG·Chang-Mu SungCheng-Tang Chiu
May 30, 2013·World Journal of Gastroenterology : WJG·Gang RenWen-Hua Li
Sep 12, 2013·World Journal of Gastroenterology : WJG·Qiang XueHan Liang
Nov 29, 2012·World Journal of Gastrointestinal Endoscopy·Koji Nagata, Michio Shimizu
Apr 20, 2014·World Journal of Gastroenterology : WJG·Jing-Yu Deng, Han Liang
May 16, 2014·Journal of Cancer Research and Clinical Oncology·Yan MaShu-Peng Zhao
Nov 15, 2006·World Journal of Surgery·Maurizio Degiuli, Fabio Calvo
Apr 1, 2014·Gastrointestinal Endoscopy Clinics of North America·Chang Beom Ryu
Jul 14, 2004·American Journal of Surgery·Nobutsugu AbeYutaka Atomi
Aug 1, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hua LiXudong Zhao
Dec 5, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong LiuHan Liang
Jan 26, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Xudong ZhaoHua Li
Jul 22, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Zheng WangZhi-Xiang Zhou
Mar 3, 2004·World Journal of Gastroenterology : WJG·Dong Yi KimShin Kon Kim
Dec 14, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hirohisa TakeuchiMasanori Sugiyama
Mar 10, 2012·Journal of the Korean Surgical Society·Yong-Hae BaikSung Kim
Feb 9, 2006·The American Journal of Gastroenterology·Massimo ConioRosangela Filiberti
Dec 31, 2015·World Journal of Gastroenterology : WJG·Tian-Jiao GuoYi-Ping Wang
Sep 28, 2016·World Journal of Gastroenterology : WJG·Atsuo ShidaKatsuhiko Yanaga

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