Risk factors that affect the degree of bronchopulmonary dysplasia: Comparison by severity in the same gestational age

PloS One
Sung-Ha KimTae-Jung Sung

Abstract

To investigate the risk factors for BPD severity by gestational age (GA) and identify a way to reduce the incidence of moderate-to-severe BPD. This was a retrospective cohort study of very-low-birth-weight-infants (VLBWIs) delivered at 24 to 28 weeks GA from Korean Neonatal Network registry between 2013 and 2016. BPD was defined using the National Institutes of Health criteria. Study populations were divided by GA and subdivided into no/mild BPD and moderate/severe BPD. The initial statuses of all infants, including those who died before BPD diagnosis and the maternal and neonatal factors of the live infants were compared. Statistical methods included descriptive statistics, comparative tests, and logistic regression. Of 3,976 infants, 3,717 were included (24weeks, n = 456; 25 weeks, n = 650, 26 weeks, n = 742; 27 weeks, n = 836; 28 weeks, n = 1,033). The overall mortality rate was 18% and the rates by GA were 43%, 29%, 11%, and 6% in the 24-, 25-, 26-, 27-, 28-GA groups, respectively. Small for GA (SGA), treated patent ductus arteriosus (PDA), hypotension, and late-onset sepsis were significant risk factors for developing moderate/severe BPD in the 25 to 28-week GA groups in the multivariate analyses. However, for infants born...Continue Reading

References

Feb 16, 1967·The New England Journal of Medicine·W H NorthwayD Y Porter
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Apr 23, 2005·American Journal of Obstetrics and Gynecology·Patrick S RamseyWaldemar Carlo
Feb 15, 2008·The New England Journal of Medicine·Colin J MorleyUNKNOWN COIN Trial Investigators
Oct 11, 2008·Seminars in Fetal & Neonatal Medicine·Boris W KramerAlan H Jobe
Apr 10, 2010·American Journal of Respiratory and Critical Care Medicine·Joseph FawkeJanet Stocks
May 18, 2010·The New England Journal of Medicine·UNKNOWN SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research NetworkRosemary D Higgins
Dec 15, 2010·Pediatrics·Namasivayam AmbalavananUNKNOWN NICHD Neonatal Research Network
Sep 21, 2011·The Journal of Pediatrics·Myra H WyckoffUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Oct 26, 2011·Pediatrics·Michael S DunnUNKNOWN Vermont Oxford Network DRM Study Group
May 23, 2012·Pediatrics·Jeffrey D HorbarJeffrey S Buzas
Apr 24, 2014·Annals of the American Thoracic Society·Cindy T McEvoyJudy L Aschner
Apr 18, 2015·The Journal of Pediatrics·Federico SchenaMonica Fumagalli
Sep 9, 2015·JAMA : the Journal of the American Medical Association·Barbara J StollUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Nov 14, 2015·Journal of Korean Medical Science·Yun Sil ChangWon Soon Park
Nov 30, 2016·Neonatology·Deidre St PeterSuma B Hoffman
Jul 15, 2017·The Journal of Pediatrics·Alan H Jobe, Robin Steinhorn
Nov 3, 2017·The Journal of Pediatrics·Sandrine LeroyPascal M Lavoie
Dec 13, 2017·Respiratory Medicine·Renjithkumar Kalikkot ThekkeveeduBinoy Shivanna
Mar 20, 2018·The Journal of Pediatrics·Rosemary D HigginsTonse N K Raju
Jul 1, 2018·Seminars in Perinatology·Ronald I Clyman
Sep 14, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Ronald I Clyman, William E Benitz

❮ Previous
Next ❯

Citations

Jun 12, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Ruben VaidyaRachana Singh

❮ Previous
Next ❯

Methods Mentioned

BETA
PMA
SGA
cesarean section

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Perinatology : Official Journal of the California Perinatal Association
M Akram KhanV Bhandari
The Journal of Pediatrics
Vincent C SmithDouglas K Richardson
Journal of Perinatology : Official Journal of the California Perinatal Association
W E TruogE K Pallotto
© 2021 Meta ULC. All rights reserved