Risk for chronic kidney disease increases with obesity: Health Survey for England 2010

Public Health Nutrition
Helen L MacLaughlinIain C Macdougall

Abstract

Studies of the relationship between obesity and chronic kidney disease (CKD) in nationally representative population samples are limited. Our study aimed to determine if overweight and obesity were independently associated with the risk for CKD in the 2010 Health Survey for England (HSE). The HSE is an annually conducted cross-sectional study. In 2010 serum creatinine was included to determine the incidence of CKD in the population. CKD was defined as estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. Multivariable logistic regression models were developed to calculate odds ratios and 95% confidence intervals for CKD risk by BMI (reference category: BMI=18.5-24.9 kg/m2) and adjusted for age, gender, ethnicity, smoking, diabetes and hypertension. A random sample of nationally representative households in England. Adults (n 3463) with calculable eGFR and BMI were included. The prevalence of CKD was 5.9%. The risk of CKD was over 2.5 times higher in obese participants compared with normal-weight participants in the fully adjusted model (BMI=30.0-39.9 kg/m2: adjusted OR=2.78 (95% CI 1.75, 4.43); BMI ≥ 40.0 kg/m2: adjusted OR=2.68 (95% CI ...Continue Reading

References

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Citations

May 15, 2016·Journal of the American Society of Nephrology : JASN·Jenna M NortonGriffin P Rodgers
Aug 16, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Nikhil MirajkarAbd A Tahrani
Sep 13, 2016·Kidney International·Hye-Young SeoIn-Kyu Lee
Sep 2, 2015·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Youssof OskrochiGraham Easton
May 9, 2018·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Elisângela Milhomem Dos SantosNatalino Salgado Filho
Jan 30, 2021·Current Obesity Reports·Maura FantiSebastian Brandhorst
Dec 15, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kate WilesLiz Lightstone
Feb 21, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Yu YanJianjun Mu
Mar 7, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chen Chen, Felicia Wu
Jul 31, 2021·Journal of Periodontal Research·Sevda Kurt-BayrakdarAdnan Yilmaz

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