Risk for colorectal cancer in persons with a family history of adenomatous polyps: a systematic review

Annals of Internal Medicine
Thomas F Imperiale, D F Ransohoff

Abstract

The risk for colorectal cancer (CRC) is unclear for persons who have first-degree relatives with adenomatous polyps (adenomas). To determine the validity of studies about this issue. MEDLINE and Cochrane databases from 1966 through 2011. Sequential review of titles, abstracts, and text from retrieved articles. Study objective, study design, and numbers in study groups. Ten studies were identified that have been used to answer the question, "Does having a first-degree relative with an adenoma increase the risk for CRC?" We determined that they instead answer the question, "Does having a first-degree relative with CRC increase the risk for an adenoma?" We identified 2 additional studies that provide more relevant information. One study showed that the risk for CRC in persons who have first-degree relatives with adenomas is greater than the risk in persons who do not have first-degree relatives with adenomas (2.31% vs. 0.53%; relative risk, 4.36 [95% CI, 1.60 to 10.21]). The other study showed that the risk for CRC or large adenomas (≥1 cm) in persons who have first-degree relatives with large adenomas is greater than the risk in persons whose first-degree relatives do not have adenomas or CRC (8.3% vs. 4.2%; adjusted odds ratio, ...Continue Reading

Citations

Feb 15, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yohei HamadaShinichi Oka
Dec 3, 2014·Clinics in Laboratory Medicine·Margaret ChoZhiheng Pei
Aug 28, 2012·Digestive Diseases and Sciences·N Jewel SamadderRandall W Burt
Jan 16, 2015·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Nora B HenriksonEvelyn P Whitlock
Sep 30, 2016·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Leslie Anne CampbellDonald MacIntosh
Aug 16, 2017·Journal of Racial and Ethnic Health Disparities·Meng-Han TsaiPiet C de Groen
Jan 27, 2019·Annals of Surgical Oncology·Soo Young LeeJae Kyun Ju
Mar 4, 2021·The American Journal of Gastroenterology·Aasma ShaukatDouglas K Rex
Jan 27, 2016·Gastroenterology·Charles J Kahi, David Lieberman

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