PMID: 9427424Jan 14, 1998Paper

Risk for endometrial cancer following breast cancer: a prospective study in Sweden

Cancer Causes & Control : CCC
H O AdamiJ K McLaughlin

Abstract

The risk for endometrial cancer among women with breast cancer might increase following use of tamoxifen, recently classified as a carcinogen of the human endometrium. However, the strength of the association remains uncertain and it is unknown whether use of this drug--widely prescribed in Sweden since the mid-1980s--has had any measurable effect at the population level. We analyzed all cases of breast cancer (n = 131,614) detected in the nationwide Swedish Cancer Registry in 1958-93. Incident cases of endometrial cancer during follow-up were identified also through the Cancer Registry. Standardized incidence ratios (SIR) and their 95 percent confidence intervals (CI) were computed by use of nationwide rates of endometrial cancer, adjusted for age and calendar year. During follow-up of up to 35 years of the breast cancer cohort, 803 incident endometrial cancers were identified, yielding an overall SIR of 1.58 (CI = 1.47-1.70). In univariate analyses, there was no increase in SIR in recent years. However, the excess risk increased linearly with increasing age at breast cancer diagnosis (P trend < 0.0001) and decreased markedly with longer follow-up (P trend < 0.0001). A multivariate regression analysis, with adjustment for age ...Continue Reading

Citations

Nov 27, 2008·Menopause : the Journal of the North American Menopause Society·Raquel P DibiGustavo P G da Silveira
May 10, 2005·International Journal of Cancer. Journal International Du Cancer·Freddie BrayElisabete Weiderpass
Aug 3, 1999·British Journal of Obstetrics and Gynaecology·B A Stoll
Apr 3, 2004·Cancer Treatment Reviews·Elzbieta Senkus-KonefkaJacek Jassem

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