PMID: 924445Nov 2, 1977Paper

Risk for short arm 10 trisomy. A segregation analysis of eleven families with different translocations

Human Genetics
J Stene, S Stengel-Rutkowski

Abstract

A segregation analysis has been carried out for 11 families with trisomy 10p caused by familial translocations involving a segment of the short arm of chromosome 10. The theoretical basis for the analysis is considered in some detail. No differences were found between the segregation pattern in the offspring of carrier mothers and that of carrier fathers. There was a high risk for offspring with trisomy 10p (22%). A phenotypically normal descendant also has a high risk of becoming a balanced translocation carrier (71%). This result does not deviate significantly from the theoretical value of 50%.

References

Dec 1, 1975·Journal of Medical Genetics·Y Nakagome, H Kobayashi
Apr 1, 1973·Annals of Human Genetics·K HirschhornI Wallace
Jan 1, 1969·British Medical Bulletin·C E Ford, H M Clegg

Citations

Jun 1, 1978·Clinical Genetics·J M ScheresH H Rutten Van Der Mee-Wienen
Apr 1, 1983·Journal of Medical Genetics·A GencíkP Auf der Maur
Dec 1, 2005·Clinical Dysmorphology·Tabib A Dabir, Patrick J Morrison
Aug 5, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ximena GoldbergLourdes Fañanás
May 1, 1985·Prenatal Diagnosis·P FargeS B Melançon
Jan 1, 1979·American Journal of Medical Genetics·D J HarrisM L Begleiter
Feb 1, 1988·American Journal of Medical Genetics·J L GorskiB S Emanuel
Jan 1, 1983·American Journal of Medical Genetics·C H GonzalezA Wajntal

Related Concepts

Chromosomes, Human,6-12
Relative Risk
Chromosomal Translocation
Partial Trisomy

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