Risk of Acute Asthma Attacks Associated With Nonsteroidal Anti-inflammatory Drugs: A Self-Controlled Case Series

Therapeutic Innovation & Regulatory Science
Yoshinori TakeuchiYoshiaki Uyama

Abstract

Although asthma attacks are known adverse events associated with nonsteroidal anti-inflammatory drug (NSAID) use, few studies have quantified these risks. The objectives of this study were to utilize an epidemiological approach to quantitatively evaluate the risk of acute asthma attacks associated with NSAID prescription in Japan and to compare the risks among NSAIDs according to their cyclooxygenase (COX)-2 selectivity. We conducted a self-controlled case series study using Japanese health insurance claims data. Exposed cases were identified as those who had experienced both NSAID prescription and acute asthma attack, which was defined as the combination of an inhalation procedure and the prescription of any inhaled β2-agonist. The incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for NSAID prescription periods compared with baseline periods were calculated using conditional Poisson regression models; COX-2 selective and nonselective NSAIDs were similarly compared. We identified 9769 subjects, more than 95% of whom were younger than 60 years. There was a significantly higher risk of acute asthma attacks during the NSAID prescription period when compared with the baseline period. The quantified IRRs were, in desce...Continue Reading

References

Apr 22, 1995·Lancet·A Szczeklik
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·T D WarnerJ R Vane
Jan 9, 2004·American Journal of Respiratory and Critical Care Medicine·R Graham BarrCarlos A Camargo
Feb 21, 2004·BMJ : British Medical Journal·Christine JenkinsLinda Hodge
Mar 1, 2005·American Journal of Respiratory and Critical Care Medicine·Tricia M McKeeverPatricia A Cassano
Oct 13, 2005·Statistics in Medicine·Heather J WhitakerPatrick Musonda
Nov 8, 2005·Biological & Pharmaceutical Bulletin·Masahiro NoguchiMasao Sasamata
Mar 9, 2006·The Journal of Allergy and Clinical Immunology·Neil W JohnstonMalcolm R Sears
Oct 13, 2006·The Journal of Allergy and Clinical Immunology·Donald D Stevenson, Andrew Szczeklik
May 24, 2008·Biostatistics·C Paddy FarringtonMounia N Hocine
Aug 30, 2008·BMJ : British Medical Journal·Heather Whitaker
Feb 13, 2009·Current Allergy and Asthma Reports·Donald D Stevenson
Dec 3, 2011·The Journal of Allergy and Clinical Immunology·David J JacksonSebastian L Johnston
Jan 25, 2012·Pharmacoepidemiology and Drug Safety·Malcolm MaclureDavid Madigan
Jun 27, 2013·BMC Medical Research Methodology·Emmae N RamsayElizabeth E Roughead
Sep 10, 2013·Journal of Clinical Epidemiology·Paddy Farrington
Oct 15, 2013·The British Journal of Dermatology·J L CorzoM J Torres
Mar 19, 2014·Journal of Internal Medicine·J Hallas, A Pottegård

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Citations

Feb 24, 2021·Allergology International : Official Journal of the Japanese Society of Allergology·Toshiki FukasawaHisashi Urushihara
May 1, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Soichiro HozawaMasayoshi Koinuma

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