Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China

Breast Cancer Research and Treatment
Xiao-Hui ChenYu-Mei Feng

Abstract

The high morbidity and aggressive behavior of breast cancer are associated with genetic variations. Single nucleotide polymorphisms (SNPs) in many genes have been demonstrated as a risk factor for breast cancer. In this study, we evaluated the association of the SNP rs1982073 (Leu10Pro) in transforming growth factor-beta 1 (TGFB1) gene and the SNP rs1219648 in fibroblast growth factor receptor 2 (FGFR2) gene with the risk and aggressiveness of breast cancer among women of Han nationality in North China. TaqMan allelic discrimination assay was performed to genotype rs1982073 and rs1219648 in 447 breast cancer cases and 406 age-matched healthy controls. The results imply that genotype frequencies of rs1982073 and rs1219648 were not significantly different between breast cancer patients and healthy controls. However, for TGFB1 SNP rs1982073, the C-carriers (T/C+C/C genotype) were more likely to bear tumors of greater aggressiveness (histological grade III) than T/T-carriers (grade I-II) (OR = 3.45, 95% CI: 1.48-8.00, P = 0.004). For FGFR2 SNP rs1219648, G-carriers (A/G+G/G genotype) were more significantly linked to tumors with lymph node metastasis than those with A/A genotype (lymph node negative) (OR = 1.69, 95% CI: 1.11-2.58, ...Continue Reading

References

Jul 2, 1973·European Journal of Biochemistry·M Gross-BellardP Chambon
Oct 1, 1995·In Vitro Cellular & Developmental Biology. Animal·S L AtkinM C White
Oct 5, 2001·Nature Genetics·R DerynckA Balmain
Nov 2, 2001·Trends in Molecular Medicine·J G TaylorS J Chanock
Dec 12, 2001·Pharmacogenetics·E HustertL Wojnowski
Oct 5, 2002·Stroke; a Journal of Cerebral Circulation·Giorgio GhilardiRoberto Scorza
Jul 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anita B Roberts, Lalage M Wakefield
Aug 12, 2004·International Journal of Cancer. Journal International Du Cancer·Qianren JinAsta Försti
May 3, 2005·Cytokine & Growth Factor Reviews·Richard Grose, Clive Dickson
Jun 9, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aesun ShinWei Zheng
Sep 6, 2005·Cancer Research·Helen DaviesP Andrew Futreal
Aug 15, 2006·Biochimica Et Biophysica Acta·Katerina Pardali, Aristidis Moustakas
Oct 5, 2006·Journal of the National Cancer Institute·UNKNOWN Breast Cancer Association Consortium
Oct 13, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A M González-Zuloeta LaddC M van Duijn
Mar 21, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ye-Sheng WeiLin Zhang
May 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Leon RaskinStephen B Gruber
Feb 13, 2009·International Journal of Molecular Medicine·Yuriko Katoh, Masaru Katoh
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

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Jan 16, 2013·Journal of Epidemiology·Wenming CaoJi-Cheng Li
May 23, 2013·Medicinal Research Reviews·Masaru Katoh, Hitoshi Nakagama
Apr 15, 2020·PLoS Computational Biology·Olga A VsevolozhskayaDmitri V Zaykin

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