Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study

Lancet
D HaubekMogens Kilian

Abstract

Periodontitis is a loss of supporting connective tissue and alveolar bone around teeth, and if it occurs in an aggressive form it can lead to tooth loss before the age of 20 years. Although the cause of periodontitis in general remains elusive, a particular clone (JP2) of the gram-negative rod Aggregatibacter (Actinobacillus) actinomycetemcomitans is considered a possible aetiological agent of the aggressive form in adolescents living in or originating from north and west Africa, where the disease is highly prevalent. We did a population-based longitudinal study of adolescents to assess the role of the JP2 clone in the initiation of aggressive periodontitis. A total of 700 adolescents from public schools in Rabat, Morocco, were enrolled in the study. We used PCR to detect A actinomycetemcomitans in plaque samples (taken from molar and incisor sites) and to differentiate between the JP2 clone and other non-JP2 genotypes of the bacterium. 18 individuals were found to already have periodontitis and were excluded. The 682 periodontally healthy adolescents (mean age 12.5 years; SD 1.0) were classified according to their A actinomycetemcomitans carrier status at baseline. After 2 years, 428 (62.8%) individuals returned for re-examina...Continue Reading

References

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Citations

Jan 17, 2012·Clinical Oral Investigations·Holger JentschSigrun Eick
Dec 20, 2012·Infection and Immunity·Benjamin KrämerPanos N Papapanou
Oct 1, 2010·Journal of Clinical Microbiology·Daniel H FineKabilan Velliyagounder
Jul 26, 2012·International Journal of Dentistry·Elerson Gaetti-JardimChristiane Marie Schweitzer
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Feb 21, 2009·Journal of Periodontology·Kitti TorrungruangChorkaew Grittayaphong
Dec 8, 2009·Journal of Periodontology·Valéria GelaniAna Paula Campanelli
Aug 5, 2010·Journal of Periodontology·Helen SchreinerDaniel H Fine
Dec 7, 2011·Journal of Periodontology·Jasim M AlbandarBruce J Paster
Mar 30, 2013·Journal of Periodontology·Patricia Furtado GonçalvesLuciana Macchion Shaddox
Dec 12, 2012·Medicina oral, patología oral y cirugía bucal·Simone FabriziMariano Sanz
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Mar 1, 2011·Journal of Clinical Periodontology·Maurizio S TonettiUNKNOWN Working Group 3 of Seventh European Workshop on Periodontology

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