PMID: 9539409Apr 16, 1998Paper

Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years

Alzheimer Disease and Associated Disorders
J C BreitnerK A Welsh

Abstract

The epsilon4 allele at APOE, the polymorphic locus for apolipoprotein E, increases the risk of Alzheimer disease (AD), especially among those with the homozygous epsilon4/epsilon4 genotype. In family studies, epsilon4 homozygotes typically develop AD at 55-75 years, an age range when AD is otherwise relatively infrequent. Population-based studies of the AD risk associated with allele epsilon4 (and especially with genotype epsilon4/epsilon4) are limited in number, and most such studies have included few AD cases between the ages of 55 and 75 years. In a large population-based twin registry, the screening of 12,709 men who were 62-73 years old yielded 38 prevalent cases of AD whose onset age ranged from 54 to 73. Genotype at APOE was determined for 37 of these cases and independently, for a similarly aged probability sample of 344 men from the same registry. The epsilon4 allele frequencies among the AD cases and the population samples were 0.39 and 0.15, respectively. The odds ratios (ORs) for AD were 17.7 for genotype epsilon4/epsilon4 versus epsilon3/epsilon3 and 13.8 for epsilon4/epsilon4 versus all remaining genotypes. By contrast, the ORs with heterozygous epsilon4/epsilon3 were only 2.76 versus epsilon3/epsilon3 and 2.01 ve...Continue Reading

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