Risk of Alzheimer's disease with metal concentrations in whole blood and urine: A case-control study using propensity score matching

Toxicology and Applied Pharmacology
Yu-Wan YangChi-Jung Chung

Abstract

Environmental exposure to heavy metals is suspected to result in neuropathology damage and cognitive impairment. We aimed to explore the association of Alzheimer's disease (AD) risk with the internal dose of heavy metals by constructing a hospital-based case-control study and using propensity-score-matching methods. We investigated 170 patients with AD and 264 controls from the Department of Neurology and Family Medicine, China Medical University Hospital in Taiwan. All patients with AD received clinical neuropsychological examination and cognitive-function assessments, including the mini-mental status examination and clinical dementia rating scale. We also constructed a propensity-score-matched population of 82 patients with AD and 82 controls by matching age, gender, education, and AD-related comorbidity. Blood levels with cadmium, lead, mercury, selenium, and urinary arsenic profile were measured. Logistic regression models and 95% confidence intervals (CIs) were applied to estimate AD risk. After stratification by respective quartile cutoffs of heavy metals, the AD risk of study participants with high urinary inorganic arsenic (InAs%) or low dimethylarsinic acid (DMA%) significantly increased (p < 0.05), as similarly found ...Continue Reading

Citations

Mar 12, 2019·Current Alzheimer Research·Eric E BrownAriel Graff-Guerrero
Nov 22, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Carla Garza-LombóRodrigo Franco
Mar 17, 2019·Journal of Molecular Neuroscience : MN·Geir BjørklundJan Aaseth
Aug 20, 2019·Metabolic Brain Disease·Soheila AlboghobeishMohsen Rezaei
Dec 29, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Garima SharmaHyoung-Chun Kim
Nov 26, 2020·International Journal of Molecular Sciences·Cadiele Oliana ReichertSérgio Paulo Bydlowski
Feb 24, 2021·Environmental Toxicology and Pharmacology·Churaibhon WisessaowapakJutamaad Satayavivad
May 1, 2021·International Journal of Molecular Sciences·Virginie BotteroJudith A Potashkin
Jun 3, 2020·Current Neuropharmacology·Sahil KhanMaushmi S Kumar

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