PMID: 7346822Jul 1, 1981Paper

Risk of amniocentesis and laboratory findings in a series of 1500 prenatal diagnoses

Prenatal Diagnosis
M VerjaalP E Treffers


The experiences with 1500 midtrimester prenatal diagnoses are reported. Abnormal findings of amniotic fluid investigations led to 43 therapeutic abortions. In +/- 30 per cent of the chromosome anomalies diagnosed, the significance of the effect on fetal development was inconclusive. The outcomes of all pregnancies except one are known. Fetal loss and perinatal mortality involved 69 cases, 23 (33 per cent) of which occurred within three weeks after amniocentesis. In these 23 cases there appeared to be a relationship between the degree of experience of the gynaecologist and fetal loss: 3.7 per cent when this experience was limited to a maximum of 10 punctures diminishing to 0.3 per cent with an experience of more than 50 punctures. It is concluded that the risk of an abortion due to amniocentesis decreases as the gynaecologist becomes more experienced with the puncture technique.


Jan 25, 1979·The New England Journal of Medicine·M S GolbusB D Hall
Jan 1, 1978·American Journal of Medical Genetics·L Y HsuK Hirschhorn
Feb 1, 1979·Journal of Medical Genetics·S J FunderburkI Klisak
Feb 1, 1979·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N J LeschotH J Coelingh Bennink
Dec 1, 1978·Journal of Medical Genetics·M VerjaalN J Leschot
Nov 1, 1977·British Journal of Obstetrics and Gynaecology·B GoldmanB Padeh
Oct 29, 1977·British Medical Journal·J PhilipM Madsen
Oct 28, 1978·British Medical Journal·J Philip, J Bang


Jul 1, 1987·Journal of Biosocial Science·E V DavisonD F Roberts
Mar 19, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Y PaltieliG Ohel
Jun 24, 1982·The New England Journal of Medicine·F Hecht
Jun 1, 1987·Plant Physiology·D J DyerS L Ditson
Aug 15, 1987·British Medical Journal·N J LeschotG C Christiaens
May 12, 1990·BMJ : British Medical Journal·J J WienerS C Farrow
Jun 15, 1985·American Journal of Obstetrics and Gynecology·F W HansonS Samuels
Jun 1, 2013·Seminars in Perinatology·Joshua F Nitsche, Brian C Brost
Jan 1, 1985·Early Human Development·N J LeschotP E Treffers
Jul 1, 1982·Prenatal Diagnosis·M VerjaalP E Treffers
Jan 13, 2006·Patient Education and Counseling·Myra C B van ZwietenN J Leschot
May 4, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Myra C B van ZwietenN J Leschot
Sep 3, 2004·American Journal of Obstetrics and Gynecology·John W Seeds
Jun 7, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Susan E DaltonMonique Ho
Apr 1, 1991·Prenatal Diagnosis·R L AndersonM S Golbus
Nov 1, 1985·Prenatal Diagnosis·E TerzianA C Turnbull
Mar 1, 1988·American Journal of Medical Genetics·M S VerpS Elias
Aug 1, 1985·British Journal of Obstetrics and Gynaecology·N J LeschotP E Treffers

Related Concepts

Therapeutic Abortion
Amniotic Fluid Index
Autosome Abnormalities
Fetal Mummification
Postneonatal Mortality
Neonatal Disorder
Autosomal Chromosome Disorders

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