Abstract
Users of the intrauterine device (IUD) may be at increased risk for bacterial vaginosis (BV). Our objective was to compare the incidence of BV in women using the IUD with women using combined oral contraceptives (COC), the contraceptive vaginal ring, and the contraceptive patch. We prospectively recruited women negative for BV at baseline. Monthly, for 6 months, participants returned a self-obtained vaginal smear for Gram stain by mail. BV was diagnosed by a Nugent score ≥7. We performed Cox proportional hazards regression to investigate associations between demographic and behavioral characteristics, contraceptive method, and incident BV. We enrolled 153 women negative for BV at baseline; 90 (59%) women who chose the IUD and 63 (41%) who chose COC, ring, or patch. There were 35 women with BV at one or more time points. The incidence of BV was 37.0% among IUD users and 19.3% in COC, ring, and patch users (P = 0.03). In the univariate analysis, race, IUD use, intermediate flora, and irregular vaginal bleeding were significantly associated with BV. In the adjusted model, IUD users were no more likely to acquire BV (hazards ratio [HRadj]: 1.28, 95% confidence interval [CI]: 0.53-3.06) than COC, ring, and patch users. The associati...Continue Reading
References
Feb 1, 1991·Journal of Clinical Microbiology·R P NugentS L Hillier
Mar 1, 1990·International Journal of STD & AIDS·H Moi
Jan 1, 1990·Sexually Transmitted Diseases·D AvontsP Piot
Jan 1, 1983·British Journal of Hospital Medicine·S G Dawson, J R Harris
Apr 1, 1997·Sexually Transmitted Diseases·J R SchwebkeH L Weiss
Jun 1, 1997·Contraception·M ShoubnikovaP A Mårdh
Apr 25, 2000·Annual Review of Medicine·J D Sobel
May 17, 2001·Sexually Transmitted Diseases·E H KoumansUNKNOWN CDC Bacterial Vaginosis Working Group
Nov 13, 2001·Contraception·M R JoesoefC A Ryan
Jan 5, 2002·The Journal of Infectious Diseases·Prashini MoodleyA Willem Sturm
Feb 20, 2003·International Journal of STD & AIDS·B A EvansD W G Brown
Sep 2, 2004·Obstetrics and Gynecology·Sharry VeresBart Burington
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine L HaggertyUNKNOWN PID Evaluation and Clinical Health study investigators
Nov 4, 2005·The New England Journal of Medicine·David N FredricksJeanne M Marrazzo
Dec 13, 2006·Central European Journal of Public Health·Sayeste DemirezenM Sinan Beksaç
Jan 2, 2007·Obstetrics and Gynecology·Jenifer E Allsworth, Jeffrey F Peipert
Jul 11, 2007·Sexually Transmitted Diseases·Emilia H KoumansLauri E Markowitz
Oct 4, 2007·Sexually Transmitted Infections·T L CherpesS L Hillier
Dec 14, 2007·Sexually Transmitted Diseases·Margaret RiggsWilliam Andrews
Dec 18, 2007·Contraception·Trícia LessardLuis Bahamondes
May 27, 2008·American Journal of Epidemiology·Rebecca M BrotmanDaniel O Scharfstein
Nov 12, 2010·The Journal of Infectious Diseases·Rebecca M BrotmanJane R Schwebke
Mar 15, 2011·Contraception·Gilbert G G DondersAnn Cornelis
Apr 26, 2011·American Journal of Obstetrics and Gynecology·Jenifer E Allsworth, Jeffrey F Peipert
Citations
May 13, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B WangQ Liao
Apr 24, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·X-D LiY-H Sun
Jul 30, 2015·BMC Infectious Diseases·Catriona S Bradshaw, Rebecca M Brotman
Oct 21, 2016·Archives of Gynecology and Obstetrics·Li-Ya WangYe-Huan Sun
Aug 23, 2016·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists’ Committee on Gynecologic Practice, UNKNOWN Long-Acting Reversible Contraceptive Expert Work Group
Jun 19, 2017·Contraception·Christine M BassisJason D Bell
Jan 13, 2018·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Mohamed RezkRagab Dawood
Oct 23, 2013·AIDS·Sharon L Achilles, Sharon L Hillier
Aug 30, 2017·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Mohamed RezkRagab Dawood
Apr 29, 2015·The Journal of Obstetrics and Gynaecology Research·Xiu-De LiYe-Huan Sun
Jun 28, 2019·Frontiers in Cellular and Infection Microbiology·Bingbing XiaoQian Xu
Oct 24, 2019·BMC Infectious Diseases·Maha Abdul-AzizAbdullah A Almikhlafy
Nov 24, 2018·Annals of Clinical Microbiology and Antimicrobials·András ÁdámEdit Urbán
Jun 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kathryn PeeblesUNKNOWN MTN-020/ASPIRE study team
Apr 9, 2020·Pharmaceutical Development and Technology·Amresh KumarGoutam Rath
Aug 27, 2019·Microbial Pathogenesis·Shagun GuptaIndu Bhushan
Oct 26, 2020·Microbial Pathogenesis·Ayesha Javed, Sobia Manzoor
Apr 18, 2021·Expert Review of Clinical Pharmacology·Carlo BastianelliGiuseppe Benagiano
Jun 22, 2021·Access Microbiology·Daniel Ruiz-PerezPurnima Madhivanan
Aug 1, 2021·Archives of Gynecology and Obstetrics·Bi JiangXin-Jian Zhang
Mar 6, 2018·American Journal of Obstetrics and Gynecology·Sharon L AchillesSharon L Hillier