Risk of bile duct cancer among printing workers exposed to 1,2-dichloropropane and/or dichloromethane

Journal of Occupational Health
Tomotaka SobueGinji Endo

Abstract

We conducted a retrospective cohort study to examine the risk of bile duct cancer among current and former workers in the offset color proof printing department at a printing company in Osaka, Japan. Standardized incidence ratios (SIRs) between January 1, 1985, and December 31, 2012, were estimated for the cumulative years of exposure to two chemicals, dichloromethane (DCM) and 1,2-dichloropropane (1,2-DCP), using the national incidence level as a reference. In addition, we examined risk patterns by the calendar year in which observation started. Among 106 workers with a total of 1,452.4 person-years of exposure, 17 bile duct cancer cases were observed, resulting in an estimated overall SIR of 1,132.5 (95% confidence interval (CI): 659.7-1,813.2). The SIR was 1,319.9 (95% CI: 658.9-2,361.7) for those who were exposed to both DCM and 1,2-DCP, and it was 1,002.8 (95% CI: 368.0-2,182.8) for those exposed to 1,2-DCP only. SIRs tended to increase according to years of exposure to 1,2-DCP but not DCM when a 5-year lag time was assumed. The SIRs were higher for the cohorts in which observation started in 1993-2000, particularly in cohorts in which it started in 1996-1999, compared with those in which it started before or after 1993-20...Continue Reading

References

Mar 16, 2013·Occupational and Environmental Medicine·Shinji KumagaiGaku Ichihara
Sep 10, 2013·Japanese Journal of Clinical Oncology·Akiko IkedaHideaki Tsukuma
Sep 13, 2013·Journal of Occupational Health·Etsuji OkamotoGinji Endo
Nov 25, 2014·Genome Biology·Yonatan H Grad, Marc Lipsitch

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Citations

Jun 5, 2018·Annals of Gastroenterological Surgery·Shoji KuboTakanori Aota
Jan 3, 2021·Regulatory Toxicology and Pharmacology : RTP·Wolfgang DekantJosje Arts

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