Abstract
Previous studies on metabolic factors and bladder cancer (BC) risk have shown inconsistent results and have commonly not investigated associations separately by sex, smoking, and tumor invasiveness. Among 811,633 participants in six European cohorts, we investigated sex-specific associations between body mass index (BMI), mid-blood pressure (BP, [systolic + diastolic]/2), plasma glucose, triglycerides, total cholesterol and risk of BC overall, non-muscle invasive BC (NMIBC) and muscle invasive BC (MIBC). Among men, we additionally assessed additive interactions between metabolic factors and smoking on BC risk. During follow-up, 2,983 men and 754 women were diagnosed with BC. Among men, triglycerides and BP were positively associated with BC risk overall (hazard ratio [HR] per standard deviation [SD]: 1.17 [95% confidence interval (CI) 1.06-1.27] and 1.09 [1.02-1.17], respectively), and among women, BMI was inversely associated with risk (HR: 0.90 [0.82-0.99]). The associations for BMI and BP differed between men and women (pinteraction ≤ 0.005). Among men, BMI, cholesterol and triglycerides were positively associated with risk for NMIBC (HRs: 1.09 [95% CI 1.01-1.18], 1.14 [1.02-1.25], and 1.30 [1.12-1.48] respectively), and BP ...Continue Reading
References
Sep 1, 1992·Epidemiology·D W Hosmer, S Lemeshow
Aug 1, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·K G Alberti, P Z Zimmet
Dec 21, 2002·Lancet·Sarah LewingtonUNKNOWN Prospective Studies Collaboration
Aug 26, 2003·American Journal of Epidemiology·Annamarja LindgrenJaakko Tuomilehto
Nov 5, 2003·Journal of Hypertension·Judith A Whitworth, UNKNOWN World Health Organization, International Society of Hypertension Writing Group
Jan 13, 2005·JAMA : the Journal of the American Medical Association·Sun Ha JeeJonathan M Samet
Aug 27, 2005·Clinical Chemistry·Paul D'OrazioUNKNOWN International Federation of Clinical Chemistry Scientific Division Working Group on Selective Electrodes and Point of Care T
Oct 31, 2006·The American Journal of Pathology·Stephanie Cowey, Robert W Hardy
Dec 7, 2006·International Journal of Epidemiology·Angela M WoodJohn Danesh
Sep 4, 2008·Acta Oncologica·Lotti BarlowMats Talbäck
Dec 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Inger Kristin LarsenBjørn Møller
Apr 22, 2009·International Journal of Epidemiology·Tanja StocksPär Stattin
Dec 23, 2009·PLoS Medicine·Tanja StocksPär Stattin
Jun 23, 2010·International Journal of Cancer. Journal International Du Cancer·Christel HäggströmPär Stattin
Dec 9, 2010·Cancer Causes & Control : CCC·Wegene BorenaHanno Ulmer
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cari M KitaharaJonathan M Samet
Jan 19, 2012·International Journal of Epidemiology·Mirjam J Knol, Tyler J VanderWeele
Feb 23, 2012·Hypertension·Tanja StocksPär Stattin
Apr 18, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Paul S JellingerUNKNOWN AACE Task Force for Management of Dyslipidemia and Prevention of Atherosclerosis
Aug 11, 2012·European Urology·Maximilian BurgerYair Lotan
Aug 31, 2012·Journal of the National Cancer Institute·Andrew G RenehanMarcel Zwahlen
Feb 2, 2013·PloS One·Susanne StrohmaierHanno Ulmer
Mar 19, 2013·Biochimica Et Biophysica Acta·Kristin M NiemanErnst Lengyel
Jun 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Qi QinXiang-Yi Zheng
Apr 29, 2014·International Journal of Cancer. Journal International Du Cancer·Nina RoswallJytte Halkjaer
Jun 11, 2014·Archives of Toxicology·Silvia Selinski
Aug 19, 2014·Lancet·Krishnan BhaskaranLiam Smeeth
Oct 28, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Francesco CantielloRocco Damiano
Sep 9, 2015·European Urology·Jakub DobruchStephen A Boorjian
Oct 9, 2015·JAMA Oncology·Marcus G K CumberbatchJames W F Catto
Apr 22, 2016·International Journal of Epidemiology·Frits Hm van OschMaurice P Zeegers
Jun 28, 2016·Lancet·Ashish M KamatWassim Kassouf
Aug 25, 2016·The New England Journal of Medicine·Béatrice Lauby-SecretanUNKNOWN International Agency for Research on Cancer Handbook Working Group
Jan 19, 2017·The New England Journal of Medicine·Steven B Heymsfield, Thomas A Wadden
Mar 2, 2017·BMJ : British Medical Journal·Maria KyrgiouKonstantinos K Tsilidis
Apr 9, 2017·Oncotarget·Limin ZhaoJunfang Huang
Sep 14, 2017·Epidemiology·Maya B Mathur, Tyler J VanderWeele
Oct 7, 2017·European Journal of Epidemiology·Hannah Louise BrookeRickard Ljung
Oct 14, 2017·Carcinogenesis·Silvia SelinskiKlaus Golka
Citations
Apr 23, 2020·Cancer Medicine·Helga H HektoenRandi E Gislefoss
Oct 23, 2020·International Journal of Clinical Practice·Volkan IzolUNKNOWN Bladder Cancer Study Group of Association of Urooncology, Turkey
Nov 26, 2020·PloS One·Stanley TelekaTanja Stocks
May 4, 2020·European Urology·J Alfred WitjesAntoine G van der Heijden
Jan 18, 2021·Cancer Medicine·Stanley TelekaTanja Stocks
Jul 20, 2021·Future Oncology·Matteo FerroCarlo Buonerba
Sep 5, 2021·Cancer Research·Lin YangJun Yan
Sep 17, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Chenglong YuPierre-Antoine Dugué