Risk of Breast Cancer in Women with False-Positive Results according to Mammographic Features

Radiology
Xavier CastellsBELE Study Group

Abstract

Purpose To assess the risk of breast cancer in women with false-positive screening results according to radiologic classification of mammographic features. Materials and Methods Review board approval was obtained, with waiver of informed consent. This retrospective cohort study included 521 200 women aged 50-69 years who underwent screening as part of the Spanish Breast Cancer Screening Program between 1994 and 2010 and who were observed until December 2012. Cox proportional hazards regression analysis was used to estimate the age-adjusted hazard ratio (HR) of breast cancer and the 95% confidence interval (CI) in women with false-positive mammograms as compared with women with negative mammograms. Separate models were adjusted for screen-detected and interval cancers and for screen-film and digital mammography. Time without a breast cancer diagnosis was plotted by using Kaplan-Meier curves. Results When compared with women with negative mammograms, the age-adjusted HR of cancer in women with false-positive results was 1.84 (95% CI: 1.73, 1.95; P < .001). The risk was higher in women who had calcifications, whether they were (HR, 2.73; 95% CI: 2.28, 3.28; P < .001) or were not (HR, 2.24; 95% CI: 2.02, 2.48; P < .001) associated ...Continue Reading

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Citations

Apr 1, 2016·MMW Fortschritte der Medizin·UNKNOWN Springer Medizin
Aug 24, 2018·Scientific Reports·Maged A AldhaeebiOmar M Ramahi
Jul 12, 2019·Frontiers in Human Neuroscience·Stephen WaiteSusana Martinez-Conde
Jun 16, 2021·British Journal of Cancer·Shadi AzamPer Hall

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