Abstract
Purpose To assess the risk of breast cancer in women with false-positive screening results according to radiologic classification of mammographic features. Materials and Methods Review board approval was obtained, with waiver of informed consent. This retrospective cohort study included 521 200 women aged 50-69 years who underwent screening as part of the Spanish Breast Cancer Screening Program between 1994 and 2010 and who were observed until December 2012. Cox proportional hazards regression analysis was used to estimate the age-adjusted hazard ratio (HR) of breast cancer and the 95% confidence interval (CI) in women with false-positive mammograms as compared with women with negative mammograms. Separate models were adjusted for screen-detected and interval cancers and for screen-film and digital mammography. Time without a breast cancer diagnosis was plotted by using Kaplan-Meier curves. Results When compared with women with negative mammograms, the age-adjusted HR of cancer in women with false-positive results was 1.84 (95% CI: 1.73, 1.95; P < .001). The risk was higher in women who had calcifications, whether they were (HR, 2.73; 95% CI: 2.28, 3.28; P < .001) or were not (HR, 2.24; 95% CI: 2.02, 2.48; P < .001) associated ...Continue Reading
References
Apr 17, 1998·The New England Journal of Medicine·J G ElmoreS W Fletcher
Jul 31, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J M BroedersR Holland
Sep 21, 2004·Cancer·Solveig HofvindSteinar Tretli
Jul 22, 2005·The New England Journal of Medicine·Lynn C HartmannDaniel W Visscher
Mar 16, 2006·Journal of Epidemiology and Community Health·Xavier CastellsFrancesc Macià
Sep 7, 2006·Journal of the National Cancer Institute·William E BarlowKarla Kerlikowske
Nov 21, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N PerryL von Karsa
Sep 12, 2008·Acta Radiologica·S HofvindP Skaane
Apr 30, 2009·Radiology·Sarah VinnicombeIsabel M Dos Santos Silva
Jan 20, 2010·Cancer Causes & Control : CCC·Geoffrey C KabatThomas E Rohan
Apr 2, 2010·Statistical Methods in Medical Research·Rebecca A HubbardRobert A Smith
Jan 11, 2011·Academic Radiology·Solveig Roth HoffSolveig Hofvind
Mar 25, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R RománX Castells
May 28, 2011·Breast Cancer Research and Treatment·R RománX Castells
Apr 12, 2012·Journal of the National Cancer Institute·My von Euler-ChelpinIlse Vejborg
Nov 13, 2012·Cancer Epidemiology·X CastellsUNKNOWN Cumulative False Positive Risk Group
Apr 2, 2013·Health Technology Assessment : HTA·M BondC Hyde
Jun 8, 2013·Journal of the National Cancer Institute·Jeffrey A TiceKarla Kerlikowske
Dec 17, 2014·Breast Cancer Research and Treatment·Xavier CastellsMaría Sala
Jan 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R RománX Castells
Citations
May 5, 2017·Cancer Medicine·Margarita PossoUNKNOWN BELE Study Group
Dec 15, 2017·Radiology·Solveig HofvindChristoph I Lee
Jun 18, 2019·Cancer·Marie LilleborgeSolveig Hofvind
Oct 12, 2019·Scientific Reports·Maya Alsheh AliKeith Humphreys
Apr 1, 2016·MMW Fortschritte der Medizin·UNKNOWN Springer Medizin
May 23, 2019·British Journal of Cancer·Javier LouroMaría Sala
Aug 24, 2018·Scientific Reports·Maged A AldhaeebiOmar M Ramahi
Jul 12, 2019·Frontiers in Human Neuroscience·Stephen WaiteSusana Martinez-Conde
Mar 24, 2021·PloS One·Javier LouroUNKNOWN BELE and IRIS Study Groups
Jun 16, 2021·British Journal of Cancer·Shadi AzamPer Hall
Jun 23, 2021·European Radiology·Margarita PossoUNKNOWN BELE study group
Jul 10, 2021·The Breast : Official Journal of the European Society of Mastology·Sara van BekkumMarc C J M Kock
Dec 11, 2019·Academic Radiology·Stephen WaiteStephen L Macknik
Aug 9, 2018··Jatuporn ChayakulkheereeItsara Wichakam