Risk of Cancer in Children Conceived by Assisted Reproductive Technology

Pediatrics
M M ReigstadR Storeng

Abstract

An increasing number of children are born after assisted reproductive technology (ART), and monitoring their long-term health effects is of interest. This study compares cancer risk in children conceived by ART to that in children conceived without. The Medical Birth Registry of Norway contains individual information on all children born in Norway (including information of ART conceptions). All children born between 1984 and 2011 constituted the study cohort, and cancer data were obtained from the Cancer Registry of Norway. Follow-up started at date of birth and ended on the date of the first cancer diagnosis, death, emigration, or December 31, 2011. A Cox proportional hazards model was used to calculate hazard ratios (HR) and 95% confidence intervals (CI) of overall cancer risk between children conceived by ART and those not. Cancer risk was also assessed separately for all childhood cancer types. The study cohort comprised 1 628 658 children, of which 25 782 were conceived by ART. Of the total 4554 cancers, 51 occurred in ART-conceived children. Risk of overall cancer was not significantly elevated (HR 1.21; 95% CI 0.90-1.63). However, increased risk of leukemia was observed for children conceived by ART compared with those w...Continue Reading

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Citations

Oct 18, 2016·Pediatric Blood & Cancer·Liat Lerner-GevaAdel Farhi
Nov 7, 2017·Human Reproduction·C L WilliamsA G Sutcliffe
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Jun 15, 2020·Cancer Epidemiology·Marte Myhre Reigstad, Ritsa Storeng
May 22, 2021·American Journal of Epidemiology·Sarah HjorthHedvig Nordeng

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