Abstract
Heart failure (HF) is the leading cause of death in the world and digoxin remains one of the oldest therapies for HF. However, its safety and efficacy have been controversial since its initial use and there is uncertainty about its long-term efficacy and safety. Recently, the repositioning of cardiac glycosides is to function in anti-tumor activity via multiple working pathways. It is interesting to compare the potential effects of digoxin in clinical patients and cell lines. First, we analyze patient information retrieved from the National Health Insurance Research database of Taiwan between January 1, 2000 and December 31, 2000. This retrospective study included a study cohort (1,219 patients) and a comparison cohort. Our analytical data suggested that patients taking digoxin are at an increased risk of cancers, including breast, liver, and lung cancers, during the 10-year follow-up period. In contrast to the anti-tumor function of digoxin, we further examined the potential pathway of digoxin via the cell-based strategy using several breast cancer cell lines, including MCF-7, BT-474, MAD-MB-231, and ZR-75-1. Digoxin consistently exerted its cytotoxicity to these four cell lines with various range of concentration. However, th...Continue Reading
References
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
Feb 20, 1997·The New England Journal of Medicine·UNKNOWN Digitalis Investigation Group
Dec 13, 2005·Annals of Family Medicine·Barry D WeissFrank A Hale
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Dec 8, 2006·BMC Cancer·Melissa A TroesterCharles M Perou
May 15, 2007·American Journal of Physiology. Cell Physiology·Wilhelm Schoner, Georgios Scheiner-Bobis
May 26, 2007·Biochimica Et Biophysica Acta·Andrey KulikovGeorgios Scheiner-Bobis
Jul 6, 2007·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Wilhelm Schoner, Georgios Scheiner-Bobis
Dec 6, 2008·Breast Cancer Research : BCR·Thomas P AhernLars Pedersen
Mar 28, 2009·Pharmacological Reviews·Alexei Y BagrovOlga V Fedorova
Jun 12, 2009·Drug and Alcohol Dependence·Shao-You FangKeh-Ming Lin
Aug 15, 2009·Cancer Research·Zhen WangYi Sun
Dec 18, 2009·PloS One·Andrea PerneMatthias Mayerhofer
Jul 27, 2010·British Journal of Clinical Pharmacology·Meng-Ting WangYu-Juei Hsu
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J BiggarMads Melbye
May 31, 2011·BMC Medical Research Methodology·Sandra K ThygesenHenrik T Sørensen
Aug 23, 2011·The International Journal of Biochemistry & Cell Biology·Yung-Lung ChangShih-Ming Huang
Aug 26, 2011·Biochimica Et Biophysica Acta·Wei-Ming WangYung-Lung Chang
Sep 3, 2011·Breast Cancer Research : BCR·Deborah L Holliday, Valerie Speirs
Dec 6, 2011·Cancer Discovery·Elizabeth A PlatzWilliam G Nelson
Mar 1, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert J Biggar
Mar 30, 2012·RNA·Erik S AndersonDouglas L Black
Jul 21, 2012·Science Translational Medicine·Laurie MengerGuido Kroemer
Nov 9, 2012·The New England Journal of Medicine·Sune F NielsenStig E Bojesen
Dec 6, 2012·Experimental Hematology & Oncology·Hosam A ElbazCerasela Zoica Dinu
Feb 21, 2013·Breast Cancer Research : BCR·Robert J BiggarMads Melbye
Mar 26, 2013·Oncoimmunology·Laurie MengerLorenzo Galluzzi
Apr 4, 2013·JAMA : the Journal of the American Medical Association·Travis B Murdoch, Allan S Detsky
Apr 10, 2013·Cancer·Vincent Yi-Fong SuChia-Jen Liu
May 15, 2013·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Saroj NiraulaAnthony M Joshua
Jun 12, 2013·Investigational New Drugs·M SlingerlandH Gelderblom
Dec 18, 2013·The International Journal of Biochemistry & Cell Biology·Guan-Yu LuWei-Shiang Lin
Feb 28, 2014·Breast Cancer Research and Treatment·Thomas P AhernSusan E Hankinson
Jun 5, 2014·BioMed Research International·José Manuel Calderón-MontañoMiguel López-Lázaro
Sep 7, 2014·Biochimie·Guan-Yu LuWei-Shiang Lin
Oct 28, 2016·Nature Cell Biology·Ting NiStephen J Weiss