Abstract
The incidence of cancer at sites other than the testis has been investigated in the families of 797 Norwegian and 178 Swedish patients diagnosed with testicular cancer during 1981-91. In the families of the Norwegian patients, the total number of cancers in the relatives was significantly lower than the expected number derived from national incidence rates [observed number of cancers 250, expected number of cancers 281.92, standardised incidence ratio (SIR) 0.89, 95% confidence interval (CI) 0.78-1.00]. This finding can be accounted for almost entirely by the finding of fewer than expected prostate and gastrointestinal cancers in the parents of cases. The other common cancers were found at slightly lower than or near the expected levels in the relatives. In the Swedish cohort, which accounts for less than 20% of cases, the observed number of cancers was very close to the expected number. Fourteen fathers of cases had prostate cancer compared with 27.57 prostate cancers expected, giving a SIR of 0.51 (P=0.006). Mothers had more lung cancers (ten cases observed, SIR=2.11, P=0.04) and cancers of the endometrium than expected (13 cases observed, SIR=1.73, P=0.09). These findings may be interpreted as support for theories proposing ...Continue Reading
Citations
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H Møller
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Lorenzo RichiardiPaul Brennan
Aug 21, 2007·International Journal of Andrology·E Rapley
May 16, 2008·Journal of Genetic Counseling·June A PetersMark H Greene
Oct 8, 2009·Human Molecular Genetics·Joseph H Nadeau
May 15, 2009·PloS One·Xiaoning PengJian Zhang
Mar 3, 2012·Hereditary Cancer in Clinical Practice·June A PetersMark H Greene
Apr 17, 2015·Human Molecular Genetics·Wenche KristiansenFredrik Wiklund
Dec 28, 2004·Pathology Oncology Research : POR·Sarolta GundyIstván Bodrogi
May 10, 2007·International Journal of Andrology·Lorenzo RichiardiOlof Akre
Nov 3, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Bjarni A AgnarssonJohannes Björnsson
Feb 6, 2007·International Journal of Cancer. Journal International Du Cancer·Andreas PetterssonMagnus Kaijser
Jan 6, 2007·Human Cell·Michele SalemiEnzo Vicari
Nov 28, 2008·International Journal of Cancer. Journal International Du Cancer·Victoria M ChiaKatherine A McGlynn
May 15, 2013·Nature Genetics·Charles C ChungKatherine L Nathanson
Jun 13, 2017·Nature Genetics·Zhaoming WangUNKNOWN Testicular Cancer Consortium
May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Elizabeth A RapleyUNKNOWN International Testicular Cancer Linkage Consortium
Nov 1, 2007·British Journal of Cancer·J CoffeyE A Rapley
Aug 3, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Satoru KantoYoichi Arai
Jan 11, 2007·British Journal of Cancer·R LingerE A Rapley
Jan 6, 2011·International Journal of Cancer. Journal International Du Cancer·Rikke Baastrup NordsborgOle Raaschou-Nielsen
Feb 6, 2003·Cancer·Martijn F Lutke HolzikHarald J Hoekstra
Mar 18, 2004·International Journal of Cancer. Journal International Du Cancer·Andreas PetterssonOlof Akre
Sep 1, 2000·Human Reproduction·R JacobsenH Møller
Apr 18, 2015·Cancer Medicine·Mary L McMasterMark H Greene
Oct 21, 2009·Cancer Causes & Control : CCC·Jenny N PoynterXiao-Ou Shu
Jun 24, 2018·Urology·Katie S MurrayJames A Eastham