Risk of cancer incidence and mortality associated with diabetes: A systematic review with trend analysis of 203 cohorts.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Suping LingFrancesco Zaccardi

Abstract

Whether the relative risk of cancer incidence and mortality associated with diabetes has changed over time is unknown. On August 12th, 2020, we electronically searched for observational studies reporting on the association between diabetes and cancer. We estimated temporal trends in the relative risk of cancer incidence or mortality associated with diabetes and calculated the ratio of relative risk (RRR) comparing different periods. As many as 193 eligible articles, reporting data on 203 cohorts (56,852,381 participants; 3,735,564 incident cancer cases; 185,404 cancer deaths) and covering the period 1951-2013, were included. The relative risk of all-site cancer incidence increased between 1980 and 2000 [RRR 1990 vs.1980: (1.24; 95% CI: 1.16, 1.34); 2000 vs.1990: (1.23; 1.15, 1.31)] and stabilised thereafter at a relative risk of 1.2; the relative risk of all-site cancer mortality was constant at about 1.2 from 1980 to 2010. Both magnitudes and trends in relative risk varied across cancer sites: the relative risk of colorectal, female breast, and endometrial cancer incidence and pancreatic cancer mortality was constant during the observed years; it increased for bladder, stomach, kidney, and pancreatic cancer incidence until 200...Continue Reading

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Jan 6, 2021·Cardiovascular Diabetology·Kamel MohammediMark Woodward
May 27, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Suangson SupabpholCharupong Saengboonmee

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