Abstract
Patients with atrial fibrillation (AF) are at increased risk of many adverse events, notably stroke. To prevent all adverse outcomes, integrated AF care is advocated though the potential domain for such multidisciplinary management is still unclear. Therefore, insight in the systemic nature of AF and identifying patients at risk of adverse events after oral anticoagulation is needed. The aim of this study is to first describe the risk of hospitalisation and mortality in community-dwelling older patients with AF using anticoagulants, and second to assess the association between traditional cardiac risk factors and these outcomes. A prospective cohort. General practice. 2068 patients with AF using oral anticoagulants. We calculated incidence rates (IRs) of ischaemic stroke, bleeding, hospitalisations and mortality, and compared risk factors using Cox regression between those with and without an adverse event, both for cardiac and non-cardiac causes. During a median follow-up of 2.7 (IQR 2.2-3.0) years, the IR per 100 person-years was 22.1 for hospitalisations and 6.7 for mortality. Non-cardiac events outnumbered cardiac events (IRs 15.7 vs 7.6 per 100 person-years for hospitalisation, p<0.001 and 5.0 vs 1.7, p<0.001 for mortality...Continue Reading
References
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
May 10, 2001·JAMA : the Journal of the American Medical Association·A S GoD E Singer
Mar 11, 2006·European Heart Journal·Jan HeeringaJacqueline C M Witteman
May 24, 2008·Journal of the American College of Cardiology·Emmanuel I SkalidisPanos E Vardas
Sep 19, 2009·Chest·Gregory Y H LipHarry J G M Crijns
Dec 17, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Cristina ChimentiAndrea Frustaci
Nov 29, 2011·The American Journal of Cardiology·Gerald V NaccarelliParag P Patel
Jan 29, 2013·BMJ Open·Christine Benn ChristiansenChristian Torp-Pedersen
Jul 9, 2013·The American Journal of Cardiology·Susan ColillaXianchen Liu
Aug 1, 2013·European Heart Journal·Bouwe P KrijtheJan Heeringa
Mar 22, 2014·Clinical Cardiology·Paulus KirchhofUNKNOWN ATRIUM Study Group
Apr 26, 2014·Circulation Research·Jason AndradeStanley Nattel
Apr 29, 2014·American Heart Journal·Benjamin A SteinbergJonathan P Piccini
Sep 2, 2014·European Heart Journal·Gregory Y H LipGiuseppe Boriani
Apr 10, 2015·Chest·Geert-Jan GeersingFrans H Rutten
Jan 15, 2016·Journal of Thrombosis and Haemostasis : JTH·S KaatzUNKNOWN Subcommittee on Control of Anticoagulation
Mar 10, 2016·Journal of the American Heart Association·Sean D PokorneyUNKNOWN ROCKET AF Steering Committee Investigators
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Sep 8, 2016·BMJ : British Medical Journal·Ayodele OdutayoConnor A Emdin
Dec 10, 2016·Journal of the American College of Cardiology·Antonio Gómez-OutesEmilio Vargas-Castrillón
Mar 8, 2017·American Heart Journal·Alanna M ChamberlainVéronique L Roger
Apr 30, 2017·Journal of the American Heart Association·Deirdre A LaneDipak Kotecha
May 12, 2017·Heart·Celine GallagherJeroen M L Hendriks
Sep 21, 2017·BMJ Open·Carline J van den DriesGeert-Jan Geersing
Citations
Mar 1, 2020·European Heart Journal·Carline J van den DriesGeert-Jan Geersing
Sep 5, 2020·Journal of Thrombosis and Haemostasis : JTH·Jaap SeeligUNKNOWN GARFIELD-AF investigators
Mar 21, 2021·BMC Cardiovascular Disorders·Zhaojie DongChangsheng Ma