Risk of cardiac and sudden death with and without revascularisation of a coronary chronic total occlusion

Heart
Cosmo GodinoAntonio Colombo

Abstract

The aim of this study is to evaluate the long-term risk of cardiac death and sudden cardiac death (SCD) and/or sustained ventricular arrhythmias (SVAs) in patients with coronary chronic total occlusions (CTO) revascularised versus those with CTO not revascularised by percutaneous coronary intervention (PCI). From a cohort of 1357 CTO-PCI patients, 1162 patients who underwent CTO PCI attempt were included in this long-term analysis: 837 patients were revascularised by PCI (CTO-R group) and 325 were not revascularised (CTO-NR group). Primary adverse endpoint was the incidence of cardiac death; secondary endpoint was the cumulative incidence of SCD/SVAs. Up to 12-year follow-up (median 6 year), compared with CTO-R patients, those with CTO-NR had significantly higher rate of cardiac death (13%[43/325]vs6%[48/837]; p<0.001) and SCD/SVAs (7.5%[24/325]vs2.5%[20/837]; p<0.001). The risk of cardiac death and SCD/SVAs was mainly driven by the subgroup of infarct-related artery (IRA) CTO patients and was significantly higher only in IRA CTO-NR patients (18%vs7%, p<0.001, 14%vs5%, p=0.001; IRA CTO-NR vs IRA CTO-R, respectively). At multivariable Cox hazards regression analysis, CTO-NR remains one of the strongest independent predictors of ...Continue Reading

References

Mar 23, 1995·The American Journal of Cardiology·M G BourassaR Frye
Nov 7, 2003·The New England Journal of Medicine·John P DiMarco
Feb 21, 2009·The New England Journal of Medicine·Patrick W SerruysUNKNOWN SYNTAX Investigators
Sep 24, 2011·JACC. Cardiovascular Interventions·Roxana MehranUNKNOWN Multinational Chronic Total Occlusion Registry
Mar 10, 2012·Journal of the American College of Cardiology·Paul FeferBradley H Strauss
Jan 16, 2013·International Journal of Cardiology·Cosmo GodinoAntonio Colombo
Jul 19, 2014·Journal of the American College of Cardiology·Sudhakar GeorgeUNKNOWN National Institute for Cardiovascular Outcomes Research
Aug 27, 2016·The American Journal of Cardiology·Lorenzo AzzaliniHung Q Ly

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Citations

Mar 19, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Giuseppe PintoMauro Carlino
May 28, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Andrea Di MarcoAngel Cequier
Jul 21, 2020·Expert Review of Cardiovascular Therapy·Amira AssafSing-Chien Yap
Dec 18, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Andrea ScottiAntonio Colombo
Nov 6, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Michael BehnesIbrahim Akin
May 29, 2021·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M van der GraafS C Yap
Oct 24, 2020·Journal of the American College of Cardiology·Shumpei KosugiYukihiro Koretsune

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