Oct 17, 2012

Risk of cardiovascular disease in a traditional African population with a high infectious load: a population-based study

PloS One
Jacob J E KoopmanRudi G J Westendorp


To test the inflammatory origin of cardiovascular disease, as opposed to its origin in western lifestyle. Population-based assessment of the prevalences of cardiovascular risk factors and cardiovascular disease in an inflammation-prone African population, including electrocardiography and ankle-arm index measurement. Comparison with known prevalences in American and European societies. Traditional population in rural Ghana, characterised by adverse environmental conditions and a high infectious load. Population-based sample of 924 individuals aged 50 years and older. Median values for cardiovascular risk factors, including waist circumference, BMI, blood pressure, and markers of glucose and lipid metabolism and inflammation. Prevalence of myocardial infarction detected by electrocardiography and prevalence of peripheral arterial disease detected by ankle-arm index. When compared to western societies, we found the Ghanaians to have more proinflammatory profiles and less cardiovascular risk factors, including obesity, dysglycaemia, dyslipidaemia, and hypertension. Prevalences of cardiovascular disease were also lower. Definite myocardial infarction was present in 1.2% (95%CI: 0.6 to 2.4%). Peripheral arterial disease was present ...Continue Reading

  • References48
  • Citations18


  • References48
  • Citations18


Mentioned in this Paper

Pathogenic Aspects
Immune System
Glucose Metabolism Disorders
C-reactive Protein Measurement
Low Density Lipoprotein Cholesterol Measurement
Systemic Inflammatory Response Syndrome
Electrocardiogram Q Waves Test

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