Risk of cardiovascular serious adverse events associated with varenicline use for tobacco cessation: systematic review and meta-analysis.

BMJ : British Medical Journal
Judith J Prochaska, Joan F Hilton

Abstract

To examine the risk of treatment emergent, cardiovascular serious adverse events associated with varenicline use for tobacco cessation. Meta-analysis comparing study effects using four summary estimates. Medline, Cochrane Library, online clinical trials registries, and reference lists of identified articles. We included randomised controlled trials of current tobacco users of adult age comparing use of varenicline with an inactive control and reporting adverse events. We defined treatment emergent, cardiovascular serious adverse events as occurring during drug treatment or within 30 days of discontinuation, and included any ischaemic or arrhythmic adverse cardiovascular event (myocardial infarction, unstable angina, coronary revascularisation, coronary artery disease, arrhythmias, transient ischaemic attacks, stroke, sudden death or cardiovascular related death, or congestive heart failure). We identified 22 trials; all were double blinded and placebo controlled; two included participants with active cardiovascular disease and 11 enrolled participants with a history of cardiovascular disease. Rates of treatment emergent, cardiovascular serious adverse events were 0.63% (34/5431) in the varenicline groups and 0.47% (18/3801) in ...Continue Reading

References

Jul 23, 1992·The New England Journal of Medicine·J LauT C Chalmers
Mar 1, 1990·Statistics in Medicine·S Greenland, A Salvan
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Feb 12, 1998·Annals of Internal Medicine·J LauC H Schmid
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Oct 30, 2003·The Cochrane Database of Systematic Reviews·J Critchley, S Capewell
Jun 24, 2004·BMJ : British Medical Journal·Richard DollIsabelle Sutherland
Apr 6, 2006·Statistics in Medicine·Michael J BradburnA Russell Localio
May 17, 2006·International Journal of Clinical Practice·J Foulds
Jul 11, 2006·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Jürgen BarthJürgen Bengel
Apr 5, 2007·Current Medical Research and Opinion·Kathryn E WilliamsJason Gong
Feb 7, 2008·The Cochrane Database of Systematic Reviews·J BarthJ Bengel
Jun 20, 2008·Statistical Methods in Medical Research·Ben VandermeerNatasha Wiebe
Feb 5, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Chen WangSimon Davies
Jan 20, 2010·Journal of the American College of Cardiology·Yariv GerberUNKNOWN Israel Study Group on First Acute Myocardial Infarction
Aug 19, 2010·The American Journal on Addictions·James PolingMehmet Sofuoglu
Dec 8, 2010·BMJ : British Medical Journal·Karl FagerströmMichael Messig
Feb 18, 2011·The Cochrane Database of Systematic Reviews·Kate CahillTim Lancaster
Apr 21, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jon O EbbertJ Taylor Hays
Jun 10, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·John R HughesKarl O Fagerstrom
Jul 6, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sonal SinghCurt D Furberg
Jul 6, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·J Taylor Hays
Sep 8, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Edward N Squire
Sep 8, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David J Woods, Mark D Caswell
Sep 8, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Hisato Takagi, Takuya Umemoto
Sep 8, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Larry Samuels
Nov 15, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Stephen RennardUNKNOWN Flexible Quit Date Study Group

❮ Previous
Next ❯

Citations

Sep 10, 2013·European Heart Journal·Nancy A Rigotti, Carole Clair
Aug 16, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Raka JainRobert A Schnoll
Nov 10, 2012·BMJ : British Medical Journal·Henrik SvanströmAnders Hviid
Nov 1, 2013·BMC Medical Research Methodology·James McCormackG Michael Allan
Feb 7, 2014·Addiction Science & Clinical Practice·Adam J GordonAlexander Y Walley
Feb 4, 2014·European Psychiatry : the Journal of the Association of European Psychiatrists·T RütherH J Möller
Mar 13, 2014·European Heart Journal·Catriona JenningsUNKNOWN EUROACTION PLUS Study Group
Jan 11, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Hans RollemaDaniel Bertrand
Jul 18, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kristin Veronica CarsonAdrian Jeffrey Esterman
Sep 19, 2012·European Addiction Research·Stefan AndreasKarl Mann
Jul 24, 2012·Current Opinion in Cardiology·Tobias Raupach, Jamie Brown
Nov 28, 2012·Current Cardiovascular Risk Reports·Paul A Fishman
Feb 11, 2014·Clinics in Chest Medicine·Stephen I Rennard, David M Daughton
Nov 19, 2015·Alcoholism, Clinical and Experimental Research·Henri-Jean Aubin, Amandine Luquiens
Feb 1, 2013·Revista Española De Cardiología·Enrique GalveUNKNOWN Working Group on Vascular Risk, Cardiac Rehabilitation of the Spanish Society of Cardiology
Sep 4, 2015·Annual Review of Medicine·Judith J Prochaska, Neal L Benowitz
Jan 20, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Alana M RojewskiUNKNOWN Comorbidities Workgroup of the Society for Research on Nicotine and Tobacco (SRNT) Treatment Network
Nov 21, 2015·Saudi Journal of Biological Sciences·Sayed Sartaj SohrabM K Pande
Mar 16, 2013·British Journal of Clinical Pharmacology·Henri-Jean AubinIvan Berlin
Oct 20, 2015·The Lancet. Respiratory Medicine·Frank T Leone, Robert Schnoll
Dec 26, 2012·Journal of the American Society of Hypertension : JASH·Diana M SobierajWilliam L Baker
Sep 12, 2015·The Lancet. Respiratory Medicine·Daniel KotzAziz Sheikh
Apr 4, 2015·Clinical Journal of Oncology Nursing·Rosario WippoldPaul Cinciripini
Dec 3, 2014·Biochemical and Biophysical Research Communications·Mitsuhisa KogaYasufumi Kataoka
May 15, 2015·Journal of Medical Case Reports·Elena MunariniRoberto Boffi
Jul 1, 2012·Global Heart·Harikrishnan Sivadasan Pillai, Sanjay Ganapathi
Feb 2, 2013·Journal of the American College of Cardiology·Mark J EisenbergUNKNOWN ZESCA Investigators
Feb 2, 2013·Journal of the American College of Cardiology·Neal L Benowitz, Judith J Prochaska
Mar 31, 2015·American Heart Journal·Philip T SagerWilliam B White
Mar 1, 2014·General Hospital Psychiatry·Ali Ulvi UcaFaruk Uguz
Nov 21, 2014·Current Cardiology Reports·Abhishek SharmaEdgar Lichstein

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

Comprehensive Meta - Analysis
Stata

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Sonal SinghCurt D Furberg
CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
David J Woods, Mark D Caswell
The American Journal of Medicine
Nancy A RigottiDaniel E Singer
© 2021 Meta ULC. All rights reserved