Risk of central nervous system defects in offspring of women with and without mental illness

Archives of Women's Mental Health
Aimina AyoubN Auger

Abstract

We sought to determine the relationship between maternal mental illness and the risk of having an infant with a central nervous system defect. We analyzed a cohort of 654,882 women aged less than 20 years between 1989 and 2013 who later delivered a live born infant in any hospital in Quebec, Canada. The primary exposure was mental illness during pregnancy or hospitalization for mental illness before pregnancy. The outcomes were neural and non-neural tube defects of the central nervous system in any offspring. We computed risk ratios (RR) and 95% confidence intervals (CI) for the association between mental disorders and risk of central nervous system defects in log-binomial regression models adjusted for age at delivery, total parity, comorbidity, socioeconomic deprivation, place of residence, and time period. Maternal mental illness was associated with an increased risk of nervous system defects in offspring (RR 1.76, 95% CI 1.64-1.89). Hospitalization for any mental disorder was more strongly associated with non-neural tube (RR 1.84, 95% CI 1.71-1.99) than neural tube defects (RR 1.31, 95% CI 1.08-1.59). Women at greater risk of nervous system defects in offspring tended to be diagnosed with multiple mental disorders, have mor...Continue Reading

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Citations

Feb 27, 2020·The International Journal of Eating Disorders·Zharmaine AnteNathalie Auger
Jan 26, 2020·British Journal of Anaesthesia·Nathalie AugerNelson Piché
Sep 1, 2020·Caries Research·Nathalie AugerBelinda Nicolau

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