Risk of cerebrovascular events associated with antidepressant use in patients with depression: a population-based, nested case-control study

The Annals of Pharmacotherapy
Yan ChenNick C Patel

Abstract

Given the widespread use of antidepressants and the negative consequence of cerebrovascular events (CVEs), an evaluation of the risk of CVEs associated with antidepressants is warranted. To examine the association between the use of an antidepressant and risk of CVEs among patients diagnosed with depression. A case-control study was performed using a managed care medical claims database from 1998 through 2002. A total of 1086 cases with CVEs were identified and matched with 6515 controls by age, sex, and the year of the index date of depression. Case patients were categorized by stroke type: hemorrhagic stroke, ischemic stroke, and other CVEs. Diagnoses of depression, CVEs, and other medical comorbidities were identified based on International Classification of Diseases, Ninth Revision, codes. Patients were defined as current users (antidepressant ended < or =30 days before CVE), recent users (31-60 days before CVE), past users (61-90 days before CVE), and remote/nonusers (> or =91 days before CVE or nonuse). Cox proportional hazards regression analysis was conducted to estimate the risk of CVEs associated with antidepressant use. A 24% increased risk of a CVE was noted in patients with current exposure to selective serotonin-r...Continue Reading

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