Risk of chemotherapy-induced neutropenic complications when treating patients with non-Hodgkin lymphoma

Expert Opinion on Drug Safety
G H LymanEva Culakova

Abstract

Myelosuppression induced by cancer chemotherapy is associated with considerable morbidity and mortality. Febrile neutropenia (FN) represents an oncologic emergency requiring immediate evaluation and treatment. Resulting chemotherapy dose reductions or delays may compromise disease control and survival. While non-Hodgkin lymphoma (NHL) represents a potentially curable malignancy, there are limited data on the risk of neutropenic complications. This review represents a systematic search and evidence summary of neutropenic complications reported in randomized controlled trials (RCTs) published over the past decade in adults with NHL receiving myelosuppressive chemotherapy. Data captured include the chemotherapy regimen and dosing, the type of NHL, sample size, myeloid growth factor (MGF) use, and myelosuppression including FN and severe neutropenia and infection. Rates of neutropenic complications for commonly utilized chemotherapy regimens vary considerably across studies with FN reported in only one-fourth of study arms. Further challenges in interpreting reported rates are the variable and inconsistent use of MGF support and little or no information on delivered chemotherapy dose intensity. Considerable change in regimens, stud...Continue Reading

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May 18, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Li JiangLina Quan
Oct 26, 2018·European Journal of Cancer Care·Takuya FukushimaMinoru Okita
May 17, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Masahiro YokoyamaKiyohiko Hatake

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