Risk of chronic kidney disease in non-obese individuals with clustering of metabolic factors: a longitudinal study

Internal Medicine
Kunihito NishikawaMasayuki Yamamoto

Abstract

The impact of the clustering of metabolic factors on chronic kidney disease (CKD) in non-obese individuals remains unclear. We conducted a follow-up study of 23,894 Japanese adults (age, 18-69 years) who continuously received annual health examinations between 2000 and 2011. Obesity, high blood pressure, high triglycerides, low high-density lipoprotein (HDL) cholesterol and high fasting blood sugar were defined as metabolic factors, and CKD was defined as renal dysfunction (estimated glomerular filtration rate: <60 mL/min/1.73 m(2)) or proteinuria (dipstick test: ≥1+). The association between the clustering of metabolic factors and CKD was assessed based on the presence or absence of obesity using a Cox proportional hazard model. Of 2,867 subjects with ≥3 metabolic factors, 650 (22.7%) were non-obese. These individuals were older and had higher metabolic risks than their obese counterparts at baseline. Among the entire cohort of 23,894 subjects, 1,764 developed renal dysfunction and 904 developed proteinuria during an average follow-up period of 7.8 years. The cumulative incidence of renal dysfunction was higher (22.1% vs. 16.1%), whereas that of proteinuria was lower (10.5% vs. 14.4%), among the non-obese subjects with ≥3 meta...Continue Reading

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Citations

Sep 12, 2015·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Anis BelarbiaAbdellatif Achour
Jun 25, 2016·Clinical and Experimental Nephrology·Kunihito NishikawaMasayuki Yamamoto
Sep 16, 2017·Journal of Lipid Research·Patricia G WilsonLisa R Tannock
Jun 8, 2019·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Vera H Koch
Nov 21, 2019·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Hung-Yu ChenJin-Shang Wu
Mar 13, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Hüseyin AbdikFikrettin Şahin

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