Risk of chronic kidney disease in young adults with impaired glucose tolerance/impaired fasting glucose: a retrospective cohort study using electronic primary care records

BMC Nephrology
Ferozkhan JadhakhanParamjit Gill

Abstract

The risk of chronic kidney disease (CKD) is known to be elevated in patients with diabetes mellitus but the risk of young adults aged 18 to 40 years with impaired glucose tolerance/impaired fasting glucose (IGT/IFG) developing CKD is not well characterised. Furthermore, progression of IGT/IFG to diabetes and subsequent CKD development is not well understood. A retrospective cohort study was undertaken using The Health Improvement Network (THIN) database, a large dataset of electronic patient records. THIN database is jointly managed by IMS Health Real World Evidence Solution ( http://www.epic-uk.org/index.html ) and In Practice System (InPs). Cases were aged 18 to 40, with a diagnosis of IGT/IFG and registered at a practice contributing to THIN between 2000 and 2015. The study population consisted of 40,092 patients, including 21,454 (53.5%) female and 18,638 (46.5%) male. The median follow-up was approximately 2 years. The outcome was a diagnosis of CKD determined from either clinical coding or laboratory results. For the primary analysis the unadjusted and adjusted relative risk of CKD in IGT/IFG was compared to age, sex and practice matched controls with normoglycaemia. For the secondary analysis we compared the incidence of...Continue Reading

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Citations

Jun 12, 2020·Therapeutic Advances in Chronic Disease·Zhongai GaoBaocheng Chang
Oct 18, 2020·Journal of Clinical Medicine·Angelika Baranowska-JurkunElżbieta Bandurska-Stankiewicz
May 26, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Mariko FurukawaKazuyo Tsushita
Feb 20, 2020·Current Diabetes Reviews·Nourhan Khaled HassanNegin Ali Mohammadi

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