Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Sandra DialDick Menzies

Abstract

Antibiotic disruption of the normal intestinal flora is a well-known risk factor for Clostridium difficile-associated diarrhea. Reduced gastric acidity has been suggested as a risk factor, and we hypothesized that proton pump inhibitors, because of their potency, may be an independent risk factor for this problem. For the cohort study we identified from a pharmacy database 1187 inpatients at a Montreal teaching hospital who received antibiotics over a 9-month period beginning in August 2002. We compared patients in this group who had also received a proton pump inhibitor or an H(2) blocker with patients who had not received acid suppressive therapy. Hospital laboratory reports of positive assay results for C. difficile toxin were used to ascertain cases in the cohort. To assess the possibility that proton pump inhibitors were prescribed to patients who were sicker and had other risk factors for C. difficile infection, we did a case-control study at a second Montreal teaching hospital. Cases were defined as patients who were positive for C. difficile toxin and who had a history of diarrhea (n = 94). Control subjects were selected from among patients who had received an antibiotic and were matched to cases by ward, age within 5 y...Continue Reading

References

Oct 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A E SimorK Tsimidis
Aug 27, 1997·JAMA : the Journal of the American Medical Association·A HurwitzC E Ruhl
Mar 24, 1998·Annual Review of Medicine·C P Kelly, J T LaMont
Oct 20, 1998·The Journal of Hospital Infection·G E Bignardi
Feb 10, 2000·The New England Journal of Medicine·L KyneC P Kelly
Jan 11, 2001·The Journal of Antimicrobial Chemotherapy·J WiströmB Svenungsson
Jun 14, 2001·Best Practice & Research. Clinical Gastroenterology·C Williams
Dec 12, 2001·BMJ : British Medical Journal·J I WestbrookJ H McIntosh
Jan 5, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lorraine KyneCiarán P Kelly
Feb 1, 2002·The New England Journal of Medicine·John G Bartlett
Feb 8, 2003·Journal of Clinical Microbiology·Tracy D Wilkins, David M Lyerly
Apr 19, 2003·Journal of Gastroenterology and Hepatology·Sandeep Mukherjee
May 24, 2003·Best Practice & Research. Clinical Gastroenterology·Mark H Wilcox
Jun 26, 2003·Alimentary Pharmacology & Therapeutics·F ParenteG Bianchi Porro
Jul 12, 2003·The Journal of Hospital Infection·R CunninghamN Gaunt

❮ Previous
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Citations

Feb 16, 2011·Archives of Internal Medicine·Shoshana J HerzigEdward R Marcantonio
Nov 1, 2012·Surgery Today·Tomoharu MiyashitaTetsuo Ohta
Dec 15, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J H BooneD M Lyerly
Sep 24, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Philip O Katz, Stacey Zavala
Sep 26, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Alizah RotramelDavid B Stewart
Aug 11, 2010·Journal of General Internal Medicine·Stephanie A C HalvorsonAlan J Hunter
Sep 8, 2012·Journal of General Internal Medicine·Anupam B JenaDana P Goldman
Jan 8, 2013·Journal of General Internal Medicine·Shoshana J HerzigEdward R Marcantonio
Jul 16, 2008·Current Gastroenterology Reports·Gregory A Coté, Colin W Howden
May 31, 2008·Current Infectious Disease Reports·Bayan MissaghiRobert C Owens
Aug 10, 2007·Epidemiology and Infection·R RicciardiB A Virnig
Jun 17, 2009·Nature Reviews. Microbiology·Maja RupnikDale N Gerding
Mar 21, 2008·The New England Journal of Medicine·Timothy J S CrossAndrew K Burroughs
Feb 7, 2009·The New England Journal of Medicine·Richard C G Pollok
Oct 17, 2008·The New England Journal of Medicine·Peter J Kahrilas
Nov 4, 2011·The New England Journal of Medicine·Vivian G LooAndre Dascal
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jacques PépinLuc Lanthier
Oct 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Donna O LoweDavid N Juurlink
Jan 15, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erik R DubberkeVictoria J Fraser
Aug 5, 2010·Critical Care Medicine·Linda D Bobo, Erik R Dubberke
Jul 9, 2010·Nephrology·Rodney EddiVincent A Debari
Nov 21, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J K RandallB D George
May 23, 2012·International Journal of Clinical Practice·J J HeidelbaughY-X Yang
Oct 27, 2006·Antimicrobial Agents and Chemotherapy·Agam RaoCurtis J Donskey
Jun 8, 2006·Journal of Clinical Microbiology·Duncan R MacCannellScott Henwick
Aug 20, 2005·BMJ : British Medical Journal·Michael I Carter, Jane Murkin
May 10, 2007·Postgraduate Medical Journal·Barry Cookson
Jan 14, 2010·Gastroenterology Research and Practice·Theodore LiakakosEvangelos P Misiakos
Jul 11, 2012·Therapeutic Advances in Gastroenterology·Joel J HeidelbaughPaul C Walker
Oct 30, 2012·Critical Care : the Official Journal of the Critical Care Forum·Trupesh Chanpura, Sachin Yende
Sep 24, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jacques PépinBenoit Cossette
Oct 26, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Thomas J Louie
Sep 27, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sandra DialSamy Suissa
Sep 27, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Richard Cunningham
Jul 9, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Vivian G LooPierre René
Jul 9, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Louis ValiquetteAllison McGeer
Jul 9, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Thomas J Louie, Jon Meddings
Jul 9, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Nov 24, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Richard Fiddian-Green

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