Risk of colon cancer recurrence in relation to diabetes

Cancer Causes & Control : CCC
Jessica ChubakRebecca A Hubbard

Abstract

To describe the association between diabetes and colon cancer recurrence. We conducted a cohort study at two integrated health care delivery systems in the United States. Using tumor registry data, we identified patients aged ≥ 18 years when diagnosed with stage I-IIIA adenocarcinomas of the colon during 1995-2014. Pre-existing diabetes was ascertained via diagnosis codes. Medical records were reviewed for eligibility and to abstract recurrence and covariate information. Recurrence was ascertained beginning 90 days after the end of colon cancer treatment (i.e., cohort entry). Recurrence of any cancer or a new primary cancer at any site was a secondary outcome. We used multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CIs) for the associations between diabetes at cohort entry and study outcomes. Among the 1,923 eligible patients, 393 (16.7%) had diabetes at cohort entry. Diabetes was not associated with recurrence (HR 0.87; 95% CI 0.56-1.33) or with any subsequent cancer (HR 1.09; 95% CI 0.85-1.40). When the definition of recurrence included second primary colorectal cancer, risk was non-significantly higher in patients with diabetes than without diabetes. The risk of colo...Continue Reading

References

Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey A MeyerhardtCharles S Fuchs
Jun 12, 2004·American Journal of Epidemiology·Steven S CoughlinMichael J Thun
Nov 17, 2005·Journal of the National Cancer Institute·Susanna C LarssonAlicja Wolk
May 15, 2007·Gastroenterology·Edward Giovannucci, Dominique Michaud
Jan 12, 2011·Journal of the Korean Society of Coloproctology·Geum Youb NohYun Yong Lee
Feb 9, 2011·Medical Oncology·Taxiarchis V Kourelis, Robert D Siegel
Mar 4, 2011·The New England Journal of Medicine·Sreenivasa Rao Kondapally SeshasaiUNKNOWN Emerging Risk Factors Collaboration
Apr 8, 2011·BMC Medicine·Ryan J O DowlingVuk Stambolic
Nov 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ahmed N DehalPeter T Campbell
Feb 22, 2012·Digestive Diseases and Sciences·Longying DengLizong Shen
May 4, 2012·Cancer Causes & Control : CCC·Adedayo A OnitiloSuhail A Doi
May 18, 2012·Endocrine-related Cancer·Dara Hope Cohen, Derek LeRoith
Jun 16, 2012·Diabetes Care·Peter T CampbellSusan M Gapstur
Oct 11, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·W LuoF Gao
May 2, 2013·Journal of Cancer Research and Clinical Oncology·Francesca BellaMilena Sant
Jun 19, 2013·Cancer Epidemiology·Furha Iram CossorJessica K Paulus
Oct 10, 2013·Diseases of the Colon and Rectum·Katherine T MillsGiuseppe Gagliardi
Jan 6, 2015·BMJ : British Medical Journal·Konstantinos K TsilidisJohn P A Ioannidis
May 15, 2015·Journal of the National Cancer Institute·Joan L Warren, K Robin Yabroff
Jul 15, 2015·Clinics and Research in Hepatology and Gastroenterology·Su LuoQi-Kui Chen
Apr 28, 2016·Cancer Chemotherapy and Pharmacology·Hui-Hui Zhang, Xiu-Li Guo
Mar 30, 2018·MMWR. Morbidity and Mortality Weekly Report·Kai McKeever BullardGiuseppina Imperatore

❮ Previous
Next ❯

Citations

Feb 1, 2019·Psycho-oncology·Gaia PocobelliJessica Chubak
Nov 2, 2019·Cancer Causes & Control : CCC·Lu ChenDenise M Boudreau
Oct 31, 2019·BMC Endocrine Disorders·Ghodratollah SoltaniMohammad Amin Kerachian
Aug 10, 2021·Health Services & Outcomes Research Methodology·Rebecca A HubbardJessica Chubak

❮ Previous
Next ❯

Software Mentioned

SAS
HCSRN Virtual Data Warehouse ( VDW )

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

© 2022 Meta ULC. All rights reserved