Risk of confirmed Guillain-Barre syndrome following receipt of monovalent inactivated influenza A (H1N1) and seasonal influenza vaccines in the Vaccine Safety Datalink Project, 2009-2010.

American Journal of Epidemiology
Sharon K GreeneGrace M Lee

Abstract

An increased risk of Guillain-Barré syndrome (GBS) following administration of the 1976 swine influenza vaccine led to a heightened focus on GBS when monovalent vaccines against a novel influenza A (H1N1) virus of swine origin were introduced in 2009. GBS cases following receipt of monovalent inactivated (MIV) and seasonal trivalent inactivated (TIV) influenza vaccines in the Vaccine Safety Datalink Project in 2009-2010 were identified in electronic data and confirmed by medical record review. Within 1-42 days following vaccination, 9 cases were confirmed in MIV recipients (1.48 million doses), and 8 cases were confirmed in TIV-only recipients who did not also receive MIV during 2009-2010 (1.72 million doses). Five cases following MIV and 1 case following TIV-only had an antecedent respiratory infection, a known GBS risk factor; furthermore, unlike TIV, MIV administration was concurrent with heightened influenza activity. In a self-controlled risk interval analysis comparing GBS onset within 1-42 days following MIV with GBS onset 43-127 days following MIV, the risk difference was 5.0 cases per million doses (95% confidence interval: 0.5, 9.5). No statistically significant increased GBS risk was found within 1-42 days following ...Continue Reading

References

May 1, 1991·American Journal of Epidemiology·J D RoscelliL Pang
Sep 1, 1965·American Journal of Ophthalmology·L R Minton
Mar 1, 1980·American Journal of Epidemiology·H F RetailliauM A Hattwick
Dec 17, 1998·The New England Journal of Medicine·T LaskyR T Chen
Jan 23, 2002·Pharmacoepidemiology and Drug Safety·F DeStefano, UNKNOWN Vaccine Safety Datalink Research Group
Oct 13, 2005·Statistics in Medicine·Heather J WhitakerPatrick Musonda
Nov 8, 2005·Lancet·Richard A C Hughes, David R Cornblath
Jun 28, 2006·Archives of Internal Medicine·Richard A HughesMartin C Gulliford
Jul 11, 2006·Journal of Clinical Epidemiology·Jason M GlanzEric K France
Oct 26, 2006·JAMA : the Journal of the American Medical Association·Simon J HambidgeUNKNOWN Vaccine Safety Datalink Team
Apr 25, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Penina HaberFrank DeStefano
Jul 25, 2009·American Journal of Epidemiology·Bruce FiremanRoger Baxter
Dec 1, 2009·American Journal of Preventive Medicine·Sharon K GreeneW Katherine Yih
Jul 1, 2010·Pediatrics·Nicola P KleinUNKNOWN Vaccine Safety Datalink
Feb 4, 2011·The New England Journal of Medicine·Xiao-Feng LiangYu Wang
Apr 20, 2011·Pediatrics·James BaggsEric Weintraub
Jun 10, 2011·American Journal of Epidemiology·Lamiae Grimaldi-BensoudaUNKNOWN Lucien Abenhaim for the GBS-PGRx Study Group
Jul 20, 2011·American Journal of Preventive Medicine·Grace M LeeUNKNOWN Vaccine Safety Datalink Project

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Citations

Apr 2, 2013·European Journal of Epidemiology·Francesca GaleottiUNKNOWN ITANG study group
Jul 3, 2013·The Lancet Infectious Diseases·Lucija Tomljenovic, Yehuda Shoenfeld
Jan 15, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Claudia VellozziKaren Broder
Sep 8, 2015·Vaccines·Alberta Di PasqualeNathalie Garçon
Jun 21, 2013·Journal of the Peripheral Nervous System : JPNS·Simon Rinaldi
Apr 5, 2014·Pharmacoepidemiology and Drug Safety·Judith C MaroMartin Kulldorff
Oct 24, 2013·Vaccine·Natalie L McCarthyEric Weintraub
Aug 12, 2014·Vaccine·Michael M McNeilFrank DeStefano
Aug 26, 2016·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Lisa A GrohskopfJoseph S Bresee
Oct 19, 2017·American Journal of Epidemiology·David A Savitz, Daniel Westreich
Dec 21, 2017·American Journal of Respiratory and Critical Care Medicine·Andrea S GershonPeter Selby
Sep 26, 2012·Expert Review of Vaccines·Ali Rowhani-RahbarRoger Baxter
May 13, 2014·Pharmacoepidemiology and Drug Safety·Jürgen PrestelUNKNOWN GBS Study Group
Apr 15, 2020·Neurology·Amanda C Guidon, Anthony A Amato
May 26, 2017·Journal of Clinical Neuromuscular Disease·Kavelin RumallaManoj K Mittal
Apr 13, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Roger BaxterNicola P Klein
Feb 9, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Efe EworukeJudith C Maro
Dec 21, 2019·European Journal of Epidemiology·Yong ChenFubao Ma
Aug 10, 2019·Frontiers in Neurology·Kuo-Hsuan ChangShang-Hung Chang
Apr 8, 2020·Frontiers in Microbiology·Sarah GeogheganPaul A Offit
Jan 4, 2020·Digestive Diseases and Sciences·Venkata R SatyamFrancis A Farraye

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