Abstract
Most studies comparing women with and without pregestational diabetes mellitus have not systematically screened for fetal anomalies in early pregnancy, potentially leading to selection bias. To evaluate the risk for certain congenital anomalies in women participating in an antenatal maternal screening program. Retrospective cohort study. We studied all women who underwent antenatal maternal serum screening in Ontario from 1994 to 2000. Fetal anomalies were documented antenatally by ultrasonography or at autopsy, and postnatally diagnosed birth defects were recorded after 20 weeks gestational age for all live- and stillborn affected infants. We compared the risk of open neural tube defects and urinary tract defects among women with and without pregestational diabetes. Of 413,219 women screened during pregnancy, 2069 (0.5%) had diabetes. Compared to non-diabetic women, the adjusted odds ratios (95%CI) for neural tube and urinary tract defects among women with diabetes were 2.5 (0.9-6.8) and 2.6 (1.4-4.9), respectively. Among women who undergo second trimester maternal serum screening, pregestational diabetes is associated with an increased risk of having a fetus with an open neural tube defect or urinary tract disorder.
References
Oct 15, 1985·American Journal of Obstetrics and Gynecology·M MiodovnikT A Siddiqi
Aug 1, 1994·The Journal of Pediatrics
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Apr 1, 1996·American Journal of Obstetrics and Gynecology
Aug 2, 1997·BMJ : British Medical Journal·I F CassonS Walkinshaw
Jun 30, 2001·JAMA : the Journal of the American Medical Association·M A HoneinL Y Wong
Aug 9, 2001·QJM : Monthly Journal of the Association of Physicians·J G RayW S Chan
Jan 31, 2002·Clinics in Perinatology·C J SaphierR L Berkowitz
Apr 12, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·T FarrellT Cundy
Jul 9, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·M VääräsmäkiA-L Hartikainen
Dec 31, 2002·Lancet·Joel G RayDavid E C Cole
Mar 26, 2003·Journal of Clinical Epidemiology·Noreen GoldmanYu-Hsuan Lin
Dec 10, 2003·BMJ : British Medical Journal·P A BoydP F Chamberlain
Feb 13, 2004·Community Genetics·Lynne McLeod, Joel G Ray
May 28, 2004·Archives of Medical Research·Nancy A HessolElena Fuentes-Afflick
Citations
Nov 4, 2010·Current Diabetes Reports·Jennifer M McNamara, Anthony O Odibo
May 30, 2009·Diabetes, Obesity & Metabolism·Parri Wentzel
Apr 29, 2011·BMC Public Health·Madiha SyedZulfiqar A Bhutta
Sep 18, 2012·BMC Public Health·Hayfaa A WahabiSamia A Esmaeil
Feb 2, 2010·BMC Women's Health·Maimunah Mahmud, Danielle Mazza
Sep 11, 2013·PLoS Medicine·Sohni DeanZulfiqar A Bhutta
Jan 27, 2009·Seminars in Fetal & Neonatal Medicine·Jacky Nizard, Yves Ville
Feb 3, 2006·International Journal of Dental Hygiene·M Perno Goldie
May 31, 2006·Congenital Anomalies·Rengasamy Padmanabhan
Oct 31, 2012·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Hongdong ZhuJanet Hornbuckle
Nov 28, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Carla M Van BennekomUNKNOWN National Birth Defects Prevention Study
Oct 13, 2006·Reproductive Toxicology·Mattias GäreskogParri Wentzel
May 3, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Zohra S LassiZulfiqar A Bhutta
Dec 25, 2012·The Journal of Nutritional Biochemistry·Qiuhuan YuanAijun Hao
Nov 5, 2016·Clinical Nutrition Research·Miyoung JangMisun Park
Apr 18, 2008·Fetal Diagnosis and Therapy·M A FichterN A Papadopulos
Jan 19, 2019·Archives of Gynecology and Obstetrics·Guo-Hong XieYuan Lv
Sep 30, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Shanshan JiaZhengwei Yuan
Aug 19, 2020·PloS One·Hayfaa A WahabiYasser Sabr
Mar 1, 2012·American Journal of Physiology. Endocrinology and Metabolism·A EjdesjöU J Eriksson
Oct 11, 2017·Birth Defects Research·Roumi DebAloke K Kalla