Risk of contrast-induced nephropathy for patients receiving intravenous vs. intra-arterial iodixanol administration

Abdominal Radiology
Gregory E TongBenjamin M Yeh

Abstract

To compare the incidence of contrast-induced nephropathy (CIN) for intravenous vs. intra-arterial administration of iodixanol, compared to non-administration. We retrospectively identified 650 patients who had intravenous iodixanol-enhanced CT, 695 with intra-arterial iodixanol cardiac catheterization, 651 with unenhanced CT, and those who also had baseline and follow-up serum creatinine within 5 days of the exam. From the medical records, we recorded the gender, age, baseline and follow-up serum creatinine/eGFR; underlying renal injury risk factors; indication for imaging; contrast material administration volume, concentration, and route of administration; and use of pre-imaging prophylactic measures for CIN. Univariate and multivariate models were used to determine predictors of CIN. Baseline eGFR was lower for patients undergoing unenhanced CT than intravenous or intra-arterial patients (68 vs. 74.6 and 72.2, respectively, p < 0.01) and not different between intravenous and intra-arterial patients (p = 0.735). Simple logistic regression did not show a difference in the rate of CIN in patients who received intravenous vs. intra-arterial iodixanol (28 of 650, 4%, vs. 28 of 695, 4%, respectively, p = 0.798), nor a higher rate o...Continue Reading

References

Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kevin NashSusan Hou
Feb 7, 2003·The New England Journal of Medicine·Peter AspelinUNKNOWN Nephrotoxicity in High-Risk Patients Study of Iso-Osmolar and Low-Osmolar Non-Ionic Contrast Media Study Investigators
Sep 24, 2004·Current Medical Research and Opinion·William McClellanMarc Leiserowitz
Jan 28, 2005·Kidney International·Eugenia NikolskyGeorge Dangas
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Glenn M ChertowDavid W Bates
May 23, 2006·AJR. American Journal of Roentgenology·Brett M ElickerJeffrey C Weinreb
Aug 4, 2006·American Journal of Physiology. Renal Physiology·Kim E JieBranko Braam
Feb 24, 2009·AJR. American Journal of Roentgenology·Richard J BruceMyron A Pozniak
Apr 8, 2011·European Journal of Radiology·Shinn-Huey ChouBenjamin M Yeh
May 17, 2011·Journal of Vascular and Interventional Radiology : JVIR·Ronald P KarlsbergUNKNOWN Iodixanol Peripheral Computed Tomographic Angiography Study Investigator Panel
Aug 26, 2011·European Radiology·Fulvio StaculUNKNOWN Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR)
Jan 31, 2013·Radiology·Robert J McDonaldDavid F Kallmes
Mar 26, 2013·Radiology·Jeffrey H Newhouse, Arindam RoyChoudhury
Feb 8, 2014·International Journal of Cardiology·Giuseppe Biondi-ZoccaiGiacomo Frati

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Citations

Jun 6, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael J Ewing, John F Eidt
May 16, 2018·Investigative Radiology·Estelle C NijssenJoachim E Wildberger
Nov 12, 2019·Japanese Journal of Radiology·Yoshitaka IsakaUNKNOWN Japanese Society of Nephrology, Japan Radiological Society, and Japanese Circulation Society Joint Working Group
Aug 23, 2018·European Radiology·Ulf NymanUNKNOWN Contrast Media Committee of the Swedish Society of Uroradiology and in collaboration with the Swedish Society of Nephrology
Nov 12, 2019·Clinical and Experimental Nephrology·Yoshitaka IsakaUNKNOWN Japanese Society of Nephrology, Japan Radiological Society, and Japanese Circulation Society Joint Working Group
Nov 11, 2020·Critical Care : the Official Journal of the Critical Care Forum·Karim LakhalVincent Robert-Edan
Feb 9, 2021·Néphrologie & thérapeutique·Louis de LaforcadeUNKNOWN Commission Néphrologie Clinique de la Société Francophone de Néphrologie, Dialyse et Transplantation
Nov 12, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshitaka IsakaUNKNOWN Japanese Circulation Society Joint Working Group

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