Risk of Covert Submucosal Cancer in Patients With Granular Mixed Laterally Spreading Tumors.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Ferdinando D'AmicoBowell Group

Abstract

Granular mixed laterally spreading tumors (GM-LSTs) have an intermediate level of risk for submucosal invasive cancer (SMICs) without clear signs of invasion (covert); the optimal resection method is uncertain. We aimed to determine the risk of covert SMIC in GM-LSTs based on clinical and endoscopic factors. We collected data from 693 patients (50.6% male; median age, 69 years) with colorectal GM-LSTs, without signs of invasion, who underwent endoscopic resection (74.2%) or endoscopic submucosal dissection (25.2%) at 7 centers in Italy from 2016 through 2019. We performed multivariate and univariate analyses to identify demographic and endoscopic factors associated with risk of SMIC. We developed a multivariate model to calculate the number needed to treat (NNT) to detect 1 SMIC. Based on pathology analysis, 66 patients (9.5%) had covert SMIC. In multivariate analyses, increased risk of covert SMIC were independently associated with increasing lesion size (odds ratio per mm increase, 1.02, 95% CI, 1.01-1.03; P = .003) and rectal location (odds ratio, 3.08; 95% CI, 1.62-5.83; P = .004). A logistic regression model based on lesion size (with a cutoff of 40 mm) and rectal location identified patients with covert SMIC with 47.0% se...Continue Reading

References

Oct 19, 2000·World Journal of Surgery·S KudoA R Hart
Oct 1, 2008·Gastrointestinal Endoscopy·Shin ei KudoPaul D Hurlstone
Jul 21, 2010·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Yoshiki WadaShigeharu Hamatani
Mar 29, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Eisuke KakuYutaka Sasaki
Oct 18, 2011·International Journal of Clinical Oncology·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Jun 27, 2012·European Journal of Gastroenterology & Hepatology·René Lambert, Shinji Tanaka
Aug 13, 2013·International Journal of Colorectal Disease·Kyeong Ok KimSi Hyung Lee
Mar 8, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E RausaD C Winter
Jun 27, 2018·Diseases of the Colon and Rectum·Sean M WrennPeter A Cataldo
Jan 5, 2019·International Journal of Colorectal Disease·Ken YamashitaKazuaki Chayama

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Citations

May 17, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sergei VoskoMichael J Bourke
Jun 21, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Blake Jones
Sep 23, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Douglas K RexMohammad A Al-Haddad
Nov 29, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·João Santos-Antunes, Guilherme Macedo
Aug 12, 2021·Clinical and Experimental Gastroenterology·Tara Keihanian, Mohamed O Othman

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